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Differences In Allele & Genotype Frequencies B/W HIV (+) & HIV (-)

Differences In Allele & Genotype Frequencies B/W HIV (+) & HIV (-). Djenny Batrony. Independent Variable Vs dependent Variable. Independent variable: HIV-infected individuals Vs Uninfected individuals Dependent variable: allele frequency of particular loci or markers.

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Differences In Allele & Genotype Frequencies B/W HIV (+) & HIV (-)

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  1. Differences In Allele & Genotype Frequencies B/W HIV (+) & HIV (-) Djenny Batrony

  2. Independent Variable Vs dependent Variable • Independent variable: HIV-infected individuals Vs Uninfected individuals • Dependent variable: allele frequency of particular loci or markers

  3. B Cell Isolated From 3 Different Groups • Hemophiliac • Homosexual male • Intravenous drug user A mutation of that will cause a defect in the gene

  4. Results • No difference in frequency or no distortion between HIV infected and HIV uninfected, except in CKR5 • Therefore, no loci are involved in the retroviral infection if there are no distortion of genotype frequencies

  5. Results (Con’t)

  6. Results (Con’t) • According to this data, an individual who inherits same alleles is a homozygote and occurs in HIV uninfected individuals that have a dominant trait • Dominant trait is when the phenotype is expressed in only one copy

  7. Results (Con’t) • Moreover, an individual who inherits different alleles is a heterozygote and occurs in HIV infected individuals that have a recessive trait • Recessive trait is when the phenotype is expressed in two copies

  8. References • Dean, M., et al. 1996. Genetic restriction Of HIV-1 Infection And Progression To AIDS By A Deletion Allele Of The CKR5 Structural Gene. Science 273: 1856-1862. • O’Brien, S.J. and M. Dean. 1997. In Search Of AIDS-Resistance Genes. Scientific American 44-51.

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