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Krol, Z, Krieg, A

Knochendichtemessung für Klinik und Modellierung Bone density measurement for clinical routine and numerical modeling. Krol, Z, Krieg, A. Orthopaedic Department University Children’s Hospital Basel (UKBB ). Density definition. ρ = m / V .

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Krol, Z, Krieg, A

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  1. Knochendichtemessung für Klinik und ModellierungBone density measurement for clinical routine and numerical modeling Krol, Z, Krieg, A OrthopaedicDepartment University Children’s Hospital Basel (UKBB)

  2. Densitydefinition ρ = m / V  Bone density notion in the medical diagnostics and imaging

  3. Bone density measurement (DXA or DEXA) Dual-energy X-ray absorptiometry (DXA or DEXA) is a means of measuring bone mineral density (BMD) • How Are Bone Density Results Measured? • Upon completion of a DXA scan, the bone density of the patient is then compared to the average peak bone density of young adults of same sex and race. This score is called the "T score" and it expresses the bone density in terms of the number of standard deviations (SD) below peak young adult bone mass. • Osteoporosis is defined as a bone density T score of -2.5 SD or below. • Osteopenia(between normal and osteoporosis) is defined as a bone density T score between -1 and -2.5 SD. all women aged 65 and older;

  4. Computed tomography: Hounsfield Unit (HU) scale µ - linear X-ray intensity attenuation coefficient µxdepends on the X-ray beam energy [from NIST tables of X-ray mass attenuation coeffic.]

  5. Definition of bone density B. Helgason et al. / Clinical Biomechanics 23 (2008)

  6. Mathematical relationship between density and Young’s modulus(established empirically by correlating experimental measurements) [Young’s modulus (E) in GPa and density in g/cm3] B. Helgason et al. / Clinical Biomechanics 23 (2008)

  7. Young’s modulus vs. apparent wet density

  8. Quantitative ComputedTomography (QCT)

  9. CT Phantom

  10. Cross-sectionofthe QCT dataset

  11. Automaticrodidentification (Hough transformfilter)

  12. Estimationofthereferencedensities

  13. Derivation ofthe material parameters

  14. Quantifyingofthebonedensity in thediagnostics Fibrous dysplasia of bone (Fibröse Dysplasie)

  15. Verlauf Becken CR/DX Denosumab treatment 2005.12.07 2011.09.26 2012.03.27 2013.03.20 2013.07.29 HJ geb. 18.08.1976

  16. Verlauf Becken CT 2012 vs. CT 2014 CT 2012 CT 2014 [DerVergleichbasiert auf den überlagerten CT-Aufnahmen (gematcht CT 2012 und CT 2014)] HJ geb. 18.08.1976

  17. The QCT enables measuring of the absolute bone density Advantages for diagnostics Phantom application in the bone tratment diagnostics: Quantitative evaluation of the therapy / treatment Phantom application in the numerical bone modeling: More reliable density data for biomechanical bone modeling and simulation Conclusions

  18. Contact: zdzislaw.krol@ukbb.ch Thank youfor your attention !

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