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Action Potential Types

Action Potential Types. Fast- and Slow Response Action Potentials. Slow response: Ionic currents. Why slow response?. High dv/dt: >200 V/s High conduction velocity: 1-4 m/s Specific drug sensitivity: sodium channel blockers – (lidocaine) and tetrodotoxin. Low dv/dt: < 20 V/s

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Action Potential Types

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  1. Action Potential Types

  2. Fast- and Slow Response Action Potentials

  3. Slow response: Ionic currents Why slow response?

  4. High dv/dt: >200 V/s High conduction velocity: 1-4 m/s Specific drug sensitivity: sodium channel blockers – (lidocaine) and tetrodotoxin Low dv/dt: < 20 V/s Low conduction velocity: 0.02-0.05 m/s Specific drug sensitivity: calcium channel blockers – nifedipine, verapamil Spontaneous phase 4 depolarization Fast response: Atria Slow response: Ventricles, Purkinje Fibers. SAN, AVN

  5. Automaticity Pacemakers hierarchy: SAN,AVN, Purkinje fibers

  6. Why are fibers of the conducting system automatic? Membrane potential of SA nodal cells

  7. Pacemaker Frequency - Mechanisms

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