1 / 3

TEST ISSUES Specificity and sensitivity are not absolute PPD’s – Friend or Foe ?

Diagnostic difficulties v Experimental modelling “Current assays for TB have a shortfall in diagnostic capability”. TEST ISSUES Specificity and sensitivity are not absolute PPD’s – Friend or Foe ? Antigen discovery and cocktail design continue IFN- g or immune signature

lilike
Download Presentation

TEST ISSUES Specificity and sensitivity are not absolute PPD’s – Friend or Foe ?

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Diagnostic difficulties v Experimental modelling“Current assays for TB have a shortfall in diagnostic capability” • TEST ISSUES • Specificity and sensitivity are not absolute • PPD’s – Friend or Foe ? • Antigen discovery and cocktail design continue • IFN-g or immune signature • HOST RESPONSE ISSUES • Genetics v infection v immune response • Concurrent infections • - Para TB • - Viral infections • - Fasciola hepatica MHM-2 Gettysburg 2008

  2. Fh Mb Fasciola hepatica and M. bovis concurrent infection • Experimental model in cattle • F. hepatica infection firstM. bovis second • IFN-g measured as per diagnosis • Fasciola infection depresses the immune response to M. bovis • Implications for diagnostics / administration of vaccines • Parasite co-infection model for human disease and diagnostics ? MHM-2 Gettysburg 2008

  3. Impact of experimental models • PAST RECORD • Successive refinement: from “crude” design to natural mimic • Models can represent various stages of disease • Models map immune kinetics • FUTURE POTENTIAL • Assess test potential and antigen components • Define immune signature ? • Model concurrent infections / latency ? • Surrogate model for human disease MHM-2 Gettysburg 2008

More Related