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Macrolides

Macrolides. Macrolides consist of macrocyclic lactone (12, 14, 16 atom), the 12-membered ring macrolides are rarely used. The most prominent members of the 14-atom rings are Erythromycin and Oleandomycin. Sixteen-membered macrolides are represented by Spiramycin.

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Macrolides

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  1. Macrolides Macrolides consist of macrocyclic lactone (12, 14, 16 atom), the 12-membered ring macrolides are rarely used. The most prominent members of the 14-atom rings are Erythromycin and Oleandomycin. Sixteen-membered macrolides are represented by Spiramycin. All macrocyclic lactone may contain ketone, hydroxyl, epoxide, olefin and glycosidically linked to one amino sugar and neutral sugar as shown in Erythromycin. the amino group provides a means to form the desirable water soluble salts, since the macrocyclic lactones are slightly soluble in water.

  2. Macrolides bind to 50S ribosomal subunit, inhibiting bacterial protein synthesis. The antibacterial activity of the macrolides mainly against gram-positive organisms and it is greater than that gram-negative organisms due to its superior penetration into gram-positive organism Macrolides used in the treatment of Legionella, Campylobacter, Chlamydia and Taxoplasma infections. Macrolides are mainly bacteriostatic, but has shown bactericidal activity in high concentration against very sensitive organisms

  3. Resistance to erythromycin is usually plasmid encoded. Three mechanisms have been identified: reduced permeability of the cell membrane or active efflux; production (by Enterobacteriaceae) of esterases that hydrolyze macrolides; and modification of the ribosomal binding site by chromosomal mutation or by a macrolide-inducible or a constitutive methylase. Efflux and methylase production account for the vast majority of cases of resistance in gram-positive organisms. Cross-resistance is complete between erythromycin and the other macrolides

  4. Macrocyclic lactone Erythromycin under acidic condition is converted first to dihydrofuran then to spiroketal derivatives as presented below:

  5. Erythromycin • Free base • Stearate salt • Glucoheptonate salt • Lactobionate salt • Ethylsuccinate ester • Propionate ester

  6. Lactobionate Glucoheptonate

  7. Ethylsccinate Propionate

  8. Clarithromycin The stability of azithromycin in acidic media due to the removal of the 9-carbonyl group along with the incorporation of a weakly basic tertiary nitrogen into the macrolide.

  9. Oleandomycin Flurithromycin Orally stable due to decrease in C-9 carbonyl polarizability, the + on C9 decreased by the influence of C8-F electronegativity, thus no internal attack of C6-OH on the C9 carbonyl.

  10. Telithromycin

  11. Lincomycin Clindamycin Lincomycins • Lincomycins resemble macrolides in antibacterial spectrum and biochemical mechanism of action.

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