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INIBITORI DELL’ACETILCOLINESTERASI (AChE)

INIBITORI DELL’ACETILCOLINESTERASI (AChE). 1) reversibili, legame non covalente. INIBITORI DELL’ACETILCOLINESTERASI (AChE). 2a) reversibili, legame covalente. INIBITORI DELL’ACETILCOLINESTERASI (AChE). 2b) reversibili, legame covalente. INIBITORI DELL’ACETILCOLINESTERASI (AChE).

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INIBITORI DELL’ACETILCOLINESTERASI (AChE)

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  1. INIBITORI DELL’ACETILCOLINESTERASI (AChE) 1) reversibili, legame non covalente

  2. INIBITORI DELL’ACETILCOLINESTERASI (AChE) 2a) reversibili, legame covalente

  3. INIBITORI DELL’ACETILCOLINESTERASI (AChE) 2b) reversibili, legame covalente

  4. INIBITORI DELL’ACETILCOLINESTERASI (AChE) 3a) irreversibili: insetticidi organofosforici DFP (DIIDROPROPILFLUOROFOSFATO) PARATHION MALATHION CLORPIRIFOS

  5. INIBITORI DELL’ACETILCOLINESTERASI (AChE) 3b) irreversibili, gas nervini

  6. Anti-AChR antibodies cross-link AChRs • Cross-linked AChRs are • endocytosed more rapidly • than normal • Internalized AChRs are degraded • Fewer AChRs remain on the Post-Junctional membrane • RESULT: Less efficient neuromuscular transmission

  7. Complement binds to the Antibody-AChR complex • Membrane-attack complex (MAC) forms on the membrane • The post-junctional membrane is damaged • Fewer post-synaptic membrane folds • Reduced numbers of AChRs • Widened synaptic cleft • RESULT: Less efficient neuromuscular transmission

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