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Downstream Biomanufacturing

Downstream Biomanufacturing. The downstream portion of a biomanufacturing process is responsible for removing cells and impurities to produce the final end product that will be made available to consumers. Extracellular.

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Downstream Biomanufacturing

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  1. Downstream Biomanufacturing The downstream portion of a biomanufacturing process is responsible for removing cells and impurities to produce the final end product that will be made available to consumers.

  2. Extracellular Extracellular means that the microbes or cells used in the biomanufacturing process secrete or release the product as they grow. The product ends up in the culture medium outside the cell. Product (outside the cell) Cell

  3. Cell Separation The stage of downstream processing where the product is separated from the cells using a filter or centrifuge.

  4. Funnel lined with a coffee filter 1 tablespoon of Gravel 2 tablespoons of Sand Graduated Cylinder Filtration Apparatus A set of materials/medium (sand, gravel, paper) and equipment designed to aid in the separation of the cells from the product.

  5. Quality Control A system of monitoring the quality of the process by taking samples and testing their concentration and/or activity.

  6. Yield Percentage A mathematical way to calculate how much product was recovered after the filtration process.

  7. Standard Curve A standard curve is a method of plotting data in order to determine the level of product recovery over time.

  8. #3 #1 #2 #4 #5 #6 Concentration Percentage A number based on comparing the color of the filtrate to a known sample or “standard curve.”

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