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Farmacología Clínica

Farmacología Clínica. Dr. Carlos Fernando Estrada Garzona Departamento de Farmacología Universidad de Costa Rica. PRINCIPIOS DE FARMACOCINETICA CLINICA ESTADO ESTACIONARIO PRINCIPIOS DE FARMACODINAMIA EFICACIA CLINICA DE MEDICAMENTOS. OBJETIVOS. FARMACOCINETICA. IT = CMT/CME.

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Farmacología Clínica

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  1. Farmacología Clínica Dr. Carlos Fernando Estrada Garzona Departamento de Farmacología Universidad de Costa Rica

  2. PRINCIPIOS DE FARMACOCINETICA CLINICA • ESTADO ESTACIONARIO • PRINCIPIOS DE FARMACODINAMIA • EFICACIA CLINICA DE MEDICAMENTOS OBJETIVOS

  3. FARMACOCINETICA

  4. IT = CMT/CME

  5. t 1/2a = 0,693/Ka

  6. Cantidad absorbida = D x f f = AUC ev / AUC iv

  7. Velocidad  C max y t máx • f absoluta = AUC ev / AUC iv • f relativa = AUC ev / AUC ref • Bioequivalencia farmacocinética = + 20% • Bioequivalencia terapéutica = • EFICACIA + TOLERABILIDAD Biodisponibilidad

  8. FISIOLOGICOS • NEONATO-AM-EMBARAZO • VACIAMIENTO GÁSTRICO • PATOLOGICOS • TGI • HEPATICO • IATROGENICOS • FÁRMACOS • CYP ABSORCIÓN

  9. α glicoproteína albúmina

  10. VD = D * f / Cp PESO  Kg

  11. Concentración máxima / C máx • Dosis de carga vs dosis mantenimiento • Obesidad vs LEC aumentado • Liposoluble / hidrosoluble • Unión a proteínas plasmáticas DISTRIBUCIÓN

  12. t 1/2e = 0,693/Ke Cl = D * f / AUC

  13. FISIOLOGICOS • EDAD-SEXO-EMBARAZO-EJERCICIO • PATOLOGICOS • RENAL-HEPATICO-CARDIACO • TABAQUISMO • IATROGENICOS • INDUCCIÓN-INHIBICION ENZIMÁTICA • pH URINARIO ELIMINACION

  14. CpE o Css = Q / Cl Cinetica orden 1

  15. Goodman and Gilman'sThePharmacologicalBasis of Therapeutics, TwelfthEdition, 2011

  16. FARMACODINAMIA

  17. The Journal of Immunology, 2007, 179: 3391–3395.

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