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Research & Development of CCRAS

Research & Development of CCRAS . N.Srikanth Central Council For Research in Ayurvedic Sciences Department of AYUSH, Ministry of Health & FW Government of India New Delhi . Introduction.

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Research & Development of CCRAS

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  1. Research & Development of CCRAS N.Srikanth Central Council For Research in Ayurvedic Sciences Department of AYUSH, Ministry of Health & FW Government of India New Delhi

  2. Introduction Central Council for Research in Ayurvedic Sciences is an apex body of Dept. of AYUSH, Ministry of Health & Family Welfare, Govt. of India set up in 1978 (bifurcated from Siddha in 2011) for - • Formulation • Co-ordination • Development • Promotion of research in Ayurvedic Systems of Medicine on scientific lines.

  3. CCRAS Network Collaboration: • BHU (MR CT) • NIA(ACT) • IPGT&RA, GAU (ACT / Toxicology) • NIMHANS (MRCTs) • ICMR(GTP) • CSIR(GTP) • DRDO (Toxicology) • BARC (QA&QC) • AIIMS (Cancer CTs) • Network of 30 institutes across country • Collaboration with Academic and Research Institutes* • Demonstrated certain areas of strength

  4. Objectives • Development of safe /effective products for diseases of national and global importance. • Revalidation of certain Classical formulations for evidence on safety and efficacy. • Dissemination of research outcome through appropriate media • To provide consultancy services for research projects/drug development. • Capacity building on research methodology. • R&D support for academic / research institutes and industry.

  5. Core Areas of Research • Medicinal Plant Research • Medico-ethno-botanical Survey • Pharmacognosy • Cultivation • Drug Development • Pre -Clinical : Standardization Pharmacology • Clinical Research • Literary Research & Documentation

  6. R & D - At a glance

  7. Some significant leads & technologies • Ayush -64 for Malaria • 777 Oil for Psoriasis • Ayush-56 for Epilepsy • Ksharasutra –minimal invasive para-surgical procedure for Anal Fistula • Nutraceutical supplements - AyushPoshakaPeya & AyushPoshaka Yoga • Ayush Face pack for Melasma • Ayabringarajakarpam in Leucoderma • Brahmyadiyoga for Acute Schizophrenia • Ayushman-8 for (Mental retardation) • ShunthiGuggulu for Rheumatoid Arthritis • Ayush-82 for Diabetes mellitus • Guggulu in Obesity and Lipid disorders • Pippalyadi yoga - An Ayurvedic Oral contraceptive for females • A herbal preparation for combating stress borne syndrome in extreme cold conditions

  8. Some significant leads & technologies • KVM Syrup “A preparation for the treatment of running and stuffy nose, productive or non productive with or without fever and to a process for the preparation thereof’’ • AYUSH-AG Tablet “A process for preparation of product for Ante natal care” • AYUSH –SS granules “A process for preparation of product for post natal care” • AYUSH PG Tablet “A process for preparation of product for Ante natal care” • AYUSH LND Tablet “A process for preparation of an Ayurvedic herbomineral compound preparation” • AYUSH BALRAKSHAKLEHYAM “A process for preparation of product for paediatric care. • AYUSH PKAVALEHA “A process for preparation of product for post natal care” • AYUSH UT OINTMENT “A process for preparation of an Ayurvedic herbal compound preparation” • BAL RASAYAN – “A process for herbomineral preparation for general resistance in children. (Patent No.196916 dated)” • AYUSH GHUTTI – “A process for herbomineral formulation for children.”

  9. IPR & Commercialization • Patents Obtained : 17 • Patents Filed : 14 • Technology Transfer : 10

  10. Literary Research & Documentation

  11. Retrieval from Manuscripts

  12. Some Important Publications

  13. Medico- ethno-botanical Survey • International recognition to the herbarium at four institutes (listed in INDEX HERBARIORUM and accredited with acronyms by the New York Botanical Garden, USA) • Regional Research Institute of Himalayan Flora, Tarikhet – ‘RKT’ • National Vriksha Ayurveda Research Institute, Jhansi– ‘JHS’ • National Ayurveda Dietetics Research Institute, Bangalore – ‘RRCBI’ • Ayurveda Regional Research Institute, Itanagar – ‘ARRI’

  14. Medico- ethno-botanical Survey Digitization of Herbarium

  15. Medico- ethno-botanical Survey Major Publications

  16. Demonstrative Cultivation of Medicinal Plants No. of gardens under CCRAS : 5 (Pune, Ranikhet, Jhansi, Itanagar & Leh) Area under cultivation : 68.5 Acres approx Total No. of species under cultivation : 716 (Without repetition) No. of cultivated species represented in AFI, part-I & II : Approx. 200 Research paper published : Approx. 150 • Monographs: • Cultivation of Commiphorawightii (Guggulu) • Experimental cultivation of saffron (Kumkum) • Standard method for propagation of Guggulu plant through cutting and air layering established. • Plants being provided to Govt./NGO/Private Institutions and farmers. • Cultivation techniques established on saffron. • Know-how being given to Forest Department Govt. of Uttarakhand and other interested parties. • Experimental cultivation of many species are carried out to observe the quality and quantity of yield, suitable maturity time of the drug part and adaptability of the species to new habitat condition.

  17. Drug Standardization

  18. Pharmacology • Approx. 375 studies have been carried out for safety evaluation/biological activities since inception • Presently, 7 studies are being carried out for safety evaluation of coded Ayurvedic drugs/Bhasmas/ Rasakalpa and biological activities for 2 Ayurvedic drugs are in progress

  19. Ayurvedic Pharmacopoeia of India

  20. Ayurvedic Pharmacopoeia of India

  21. Ayurvedic Pharmacopoeia of India

  22. Ayurvedic Pharmacopoeia of India Ayurvedic Pharmacopoeia volumes in pipeline

  23. Clinical Research • Scientific validation of clinical safety and efficacy of Classical Ayurvedic formulations • Development of “Investigational New Drugs” (INDs) based on Ayurvedic principles and experimental leads

  24. Collaborative Research

  25. Current Intra Mural Clinical Trials • Rasayana in apparently healthy elderly persons • Irritable bowel syndrome • Menopausal syndrome • Dysmenorrhea • Iron deficiency anaemia • Essential hypertension • Dry eye syndrome • Allergic conjunctivitis • Osteoarthritis • Rheumatoid arthritis • Osteoporosis • Dyslipidemia • Obesity • Diabetes mellitus Type II • Bronchial Asthma • Chronic bronchitis • Cognitive deficit • 17 disease areas • 19 institutes • Validation of 26 formulations

  26. Reproductive & Child Health • Feasibility of introducing Indian systems of medicine (Ayurveda & Siddha) in the National RCH at the primary health care (PHC) Level”: An Operational Study* • 17 drugs developed • Integration with the Reproductive & Child Health program • Prevention & Management • Extent for integration and efficacy of interventions • Concluded at Himachal Pradesh in March 2013 *CCRAS-ICMR Collaborative Project

  27. R&D Support Through Extra Mural Research (EMR) • Encourage Academic and Research Organizations to pursue Research in AYUSH/TM & Related Sciences • Enrich Scientific data and Develop Innovations having IPR value

  28. Thank You

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