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Sickle Cell Anemia

Sickle Cell Anemia. Chisom Amaefuna Adeline Laurente 1/29/10 Period 2. Summary. Sickle cell anemia is a genetic blood disease due to a abnormal form of a hemoglobin. Hemoglobin is the molecule in the red blood cell that transports oxygen from lungs to the farthest parts of the body

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Sickle Cell Anemia

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  1. Sickle Cell Anemia Chisom Amaefuna Adeline Laurente 1/29/10 Period 2

  2. Summary • Sickle cell anemia is a genetic blood disease due to a abnormal form of a hemoglobin. • Hemoglobin is the molecule in the red blood cell that transports oxygen from lungs to the farthest parts of the body • Symptoms of sickle cell anemia include: • Paleness of the skin • Weakness • Shortness of breath • Heart failure • Fact: • Couples who are both carriers have a 25% chance of giving a mutated gene to a child • Sickle cell anemia is more common in middle eastern countries, Africa, Spanish-speaking countries

  3. Chromosomes Sickle Cell Anemia is located in CHROMOSOME 11

  4. Inheritance of Sickle Cell Anemia -Sickle cell is inherited in an Autosomal recessive pattern. -autosomal recessive-Genetic condition that appears only in individuals who have received two copies of an autosomal Gene -The gene is on an autosome, a nonsex chromosome -People with one defective gene and one normal gene are carriers

  5. Alleles • Alleles are another form of genes that are located on a part of the chromosomes • Humans have 46 alleles because they are attached to chromosomes • Heterozygous has one dominant and one recessive allele • Homozygous has either two dominant or two recessive alleles • Heterozygous: Rr • Homozygous: RR or rr • Dominance one parent has a faulty dominant gene which overpowers the other genes and will make the child either affected or not affected, but not a carrier. • Recessive is when both parents have a normal gene and a affected one. The parents will be carriers but not affected. Their offspring however will either be affected, not affected, or a carrier.

  6. Punnett squares S S S s S S s S s s S s S S s s

  7. Probability of Punnett squares RATIOS PERCENTAGES 25% SS: 50% Ss: 25% ss S s S SS Ss s Ss ss

  8. Genotype and Phenotype GENOTYPE What is in the GENES S represents dominant allele GREEN s represents recessive allele yellow SS=homozygous dominant (GREEN) Ss= heterozygous dominant (GREEN) ss= homozygous recessive (yellow) 25%: 50% : 25% Normal to carrier to affected PHENOTYPE What you can SEE SS= GREEN Ss= Green (yellow gene carrier) Ss= yellow 3:1 Normal to affected

  9. Genotype and Phenotype Probablilty

  10. Student Practice with Punnett Squares

  11. Pedigree KEY CIRCLE- FEMALE SQUARE- male White- normal Red-affected HALF- CARRIER

  12. Student Practice with Pedigree KEY CIRCLE- FEMALE SQUARE- male White- normal Red-affected HALF- CARRIER

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