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NAMIC Activities at UNC

NAMIC Activities at UNC. TBI. HD. Methods Engineering. I mage Analysis DTI QC via Monte Carlo Simulation Longitudinal atlases with intensity changes DTI Registration with pathology Fiber tract analysis framework Shape Analysis Longitudinal shape correspondence

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NAMIC Activities at UNC

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  1. NAMIC Activities at UNC TBI HD Methods Engineering • Image Analysis • DTI QC via Monte Carlo Simulation • Longitudinal atlases with intensity changes • DTI Registration with pathology • Fiber tract analysis framework • Shape Analysis • Longitudinal shape correspondence • Groupwise cortical correspondence • SPHARM-Particle shape analysis framework

  2. Cortical Correspondence • Goal: Flexible, group-wise cortex correspondence • Cortical thickness analysis in HD DBP • Allow for point and sulcal landmarks, longitudinal info • Existing NA-MIC particle based correspondence • No guarantee on surface mesh topology • Spherical parametrization • No explicit registration/deformation • Spherical harmonics encoding • Local angular deformation • Optimal pole choice

  3. Group-wise Correspondence • Entropy on sulcal depth & landmarks • Exponential spherical mapping • Color based correspondence QC

  4. Cortical Correspondence - Manual (ground truth) sulci mapped into average atlas space

  5. Brain Shape Regression Utah NA-MIC shape regression applied to pediatric brain shape Craniosynostosis pathologic brain development

  6. DTI QC – Error distribution • DTI/DWI noisy, artifact rich => QC needed • Rejection of bad gradients • How much rejection is still okay? • Simple threshold on numbers of rejected DWI? • Goal: Estimate error distribution via Monte Carlo • Reject dataset based on error requirements • Error in FA or principal direction

  7. DTI Error Distribution Thresholds 1% FA error for apps like HD DBP 10° error for tractography in surgical apps

  8. UNC-Utah DTI Framework • NA-MIC Algorithms from UNC, MIT, Utah, Iowa => HD and TBI DBP • Comprehensive tools • DWI/DTI QC • DWI/DTI-Atlas building • Tractography • Fiber metrics • Profile analysis • Slicer compatible • SPIE/online tutorial

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