1 / 15

GI Pathology I, Case 1

GI Pathology I, Case 1. 54-year-old man with frequent heartburn; painful, sour feeling in his chest, especially when he lies down after a meal or consuming alcohol. Describe the pathologic changes. Thickened esophageal squamous epithelium. Chronic inflammatory cells within submucosa.

lkay
Download Presentation

GI Pathology I, Case 1

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. GI Pathology I, Case 1 • 54-year-old man with frequent heartburn; painful, sour feeling in his chest, especially when he lies down after a meal or consuming alcohol.

  2. Describe the pathologic changes

  3. Thickened esophageal squamous epithelium Chronic inflammatory cells within submucosa

  4. Mucosal inflammation Necrosis of surface esophageal muscoal cells Increased vascularity of lamina propria

  5. Diagnosis:Chronic esophagitis

  6. Identify the organ and gross morphologic changes Diagnosis?

  7. Barrett Esophagus Associated with Reflux Esophagitis The upper and lower segments of the esophagus are lined by glistening, pearly-white, stratified squamous epithelium (non-keratinizing). The center segment represents intestinal metaplasia of the epithelium with chronic inflammation. The epithelium is thick, red, and "velvety."

  8. Describe the histologic findings

  9. Islands of glandular epithelium interspersed between Squamous epithelium

  10. Goblet cells Intestinal metaplasia

  11. Diagnosis:Barrett Esophagus

  12. Identify the organ Describe the gross morphologic changes

  13. Exophytic, ulcerated mass lesion Just proximal to the gastroesophageal junction Histologic sections of the mass showed malignant glands consistent with Adenocarcinoma arising from Barrett esophagus

More Related