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The Research Question

This research compares the sensitivity and specificity of osteoporosis risk assessment tools in women aged 50-64 and evaluates the effectiveness of a FRAX score threshold of 9.3%. The study suggests that alternative tools like SCORE could improve sensitivity in detecting osteoporosis.

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The Research Question

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Presentation Transcript

  1. The Research Question Comparison of Osteoporosis Risk Assessment Tools in Women 50-64 Years Old Jennifer L. Pecina MD, Lindy Romanovsky, MDStephen P. Merry MD, Kurt A. Kennel MD, Tom D. Thacher MD • How does the sensitivity and specificity of a FRAX score threshold of 9.3% compare to other osteoporosis prediction tools? • Why this is important? • USPSTF recommends this threshold to consider osteoporosis screening in this age group • Previous study by authors suggested this threshold is not very sensitive to detect osteoporosis in this age group • Alternate prediction tools may have better sensitivity

  2. What the Researchers Did • Population: 290 women ages 50-64.5 years who had DXA performed over a 6 month period • Design: Retrospective record review • Basic Method/Intervention • sensitivity, specificity, area under the receiver operating characteristic curve (AUC), determined for each clinical prediction tool below • FRAX threshold of 9.3%, OST, ORAI and SCORE tools evaluated

  3. What the Researchers Found • SCORE was most sensitive for detecting osteoporosis • Reducing the FRAX threshold to 6.8% increased its sensitivity for detecting osteoporosis

  4. What This Means for Clinical Practice • FRAX threshold of 9.3% not very sensitive to detect osteoporosis in women ages 50-64 years old • Lowering the FRAX threshold to 6.8% could improve sensitivity • Utilizing alternative tool (SCORE) could improve sensitivity

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