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University of Florida Institute on Aging Claude D. Pepper Older Americans Independence Center

University of Florida Institute on Aging Claude D. Pepper Older Americans Independence Center . Marco Pahor, MD. www.aging.ufl.edu. UF Pepper Center 2007-2017. The theme Sarcopenia and prevention of disability

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University of Florida Institute on Aging Claude D. Pepper Older Americans Independence Center

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  1. University of Florida Institute on Aging Claude D. Pepper Older Americans Independence Center Marco Pahor, MD www.aging.ufl.edu

  2. UF Pepper Center 2007-2017 The theme Sarcopenia and prevention of disability is being pursued using an interdisciplinary approach that traverses the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology and health services

  3. UF Pepper Center Mission • To assess the risk factors and better understand the biological mechanisms of physical disability in older adults • To develop and test effective prevention and rehabilitation therapies • To train future leaders and researchers in the arena of aging and disability

  4. University of Florida Institute on Aging OAIC in numbers – 2007 - 2013 • 55 active research projects • 68 completed research projects • 15 pending grants • 50 funded investigators at 16 institutions • 45 trainees • 13 partnering UF colleges • 54,000 sq. ft. of office, research, clinical space

  5. Interactions of the Pepper Center with Colleges, Institutes, Centers & Other Organizations Health Sciences Colleges Other Colleges Medicine Public Health & Health Prof. Nursing Liberal Arts & Sciences Health & Human Performance IFAS Pharmacy Dentistry Veterinary Medicine Engineering Journalism & Communicat. Law Fine Arts Institutes & Centers Hospitals Cognitive Aging Pepper Center Shands Hospital CTSI Genetics Institute VA Hospital Cancer Center Brain Institute Community Partners Trainees Fellows, Residents, T-K trainees, Junior Faculty, Study Coordinators, Students Corporate Partners Emerging Pathogens Inst. VA GRECC

  6. Institute on Aging Clinical Translational Research Building – NIH C06RR029852

  7. Institute on Aging Health Promotion Research Center

  8. UF Institute on Aging - Orlando Lake Nona Academic & Research Center

  9. Major Phase 3 randomized controlled trials with disability outcomes in older persons • The Life Study • The TTrial • ASPREE

  10. Active Clinical Pilot Studies

  11. Automaticity of walking: Age-related impairment and functional implications (Clark) • To determine if peripheral sensory impairment increases cortical demand of walking and if increased cortical demand of walking reduces mobility function. • Test the hypothesis that electromyographic (EMG) measures are more sensitive than gait parameters to determine cortical demand using a dual-tasking paradigm in older adults.

  12. Pending/Emerging Clinical Studies

  13. Pepper Junior Scholars and Affiliate Pepper Scholars • S. Someya Aging & Geriatric Research (9% RO1 Age-related hearing loss NIDCD) • K. Sibille, Community Dentistry (score 24 K-Award) (pain, OA, telomere biology) • D. Clark, Brain Rehabilitation Research Center, VA (VA Career Dev. Award) • A. Judge, Physical Therapy (RO1 funded on Basic Muscle Biology, not Aging, yet) • V. Dotson, Clinical & Health Psychology, Minority Supplement Funded/R21 pending • T. Buford, Aging & Geriatric Research (AHA and ADA grants submitted) • AM Joseph, Aging & Geriatric Research (Pepper Pilot Grant Funded) • Affiliated Scholars • Silvia Tornaletti (Pepper Pilot Grant funded) • Phil Efron (Pepper Pilot Grant funded) • Natalie Ebner (Department of Psychology) (Submitting RO1 in response to RFA) • Mark Wallet (Department of Pathology, Immunology and Laboratory Medicine) • Peter Adhihetty (Department of Applied Physiology)

  14. RCDC Activities -Roundtable Discussion (Academic Topics/ Grant Review) Combined with CTSI Scholars -Semi-Annual Discussion on Academic Progress -regular mentee/mentor committee meetings & formal feedback -Seminar Series -Workshops Grant Review Specialty Area Workshops -Travel and Pilot Grant Support

  15. Induced pluripotent stem cells (iPSCs): potential model to study mechanisms of human aging (Joseph, PhD and Terada, PhD) iPSCs are a type of pluripotent stem cell artificially derived from a non-pluripotent cell - typically an adult somatic cell- by inducing a "forced" expression of specific genes. Terada. Laboratory Investigation (2011) 91, 972–977

  16. Continue: induced pluripotent stem cell (iPSC) study • Establishment and characterization of human iPS cells for ES cell properties including stem cell markers, self-renewal, and pluripotency • In vitro differentiation of muscle cells from human iPS cells. • Determine the mechanisms of mitochondrial/autophagy alterations of iPS cells derived from individuals of disparate ages.

  17. Role of mitochondrial DNA repair in aging and sarcopenia (Silvia Tornaletti, PhD) • The present project aims at identifying molecular mechanisms associated with the age-related features of sarcopenia by studying the relation of mitochondrial DNA stability with DNA repair efficiency and TFAM binding. • We will investigate changes with declining physical function

  18. Sepsis/Trauma in the Elderly (Efron, Scientist and ICU MD) • Prolonged ICU stays and Manageable Organ Dysfunctions • Recurrent Infections (Hits) and Persistent Acute Phase Response & Decreased Lymphocytes • Decreased Lean Body Mass – a Wasting Disease and Poor Wound Healing • Transfer to LTACs for Indolent Deaths • Older Adults 25% discharged to SNFs and 1/3rddead within one year. • Overall Mortality Sespsis patients 20% Elderly Mortality 40% • Majority will have Cognitive and Functional Impairments in survivors

  19. Immune Mechanisms in the Elderly in Response to Severe Sepsis and Trauma. Animal Models Needed to Understand Trauma/Sepsis syndrome in the elderly • Characterize the emergency myelopoietic response during severe sepsis and severe polytrauma in the aged versus the young adult mouse. • Examine whether increased dysregulation and delay in the emergency myelopoiesis response after sepsis or trauma is responsible, in part, for the immune suppression that leads to increased susceptibility and/or mortality to secondary infections in the elderly as compared to the young.

  20. Future Directions • Impact of cognition, memory and pain on physical function and sarcopenia • Mitochondrial function • Pharmacological, nutritional and behavioral interventions to improve/maintain physical and cognitive function (LIFE-Extension Study, LIFE-ARISE prevention of AD, inflammation, vitamin D) • Multimodality intervention studies

  21. Our OAIC Leaders M. Pahor, MD S. Anton, PhD C. Carter, PhD R. Cohen, PhD L. Crump, MPH H. Doss, PhD C. Leeuwenburgh, PhD T. Manini, PhD M. Marsiske, PhD S. Nayfield MD

  22. Pepper Junior Scholars Our Leaders of Tomorrow D. Clark, PhD T. Buford, PhD V. Dotson, PhD A. Joseph, PhD A. Judge, PhD K. Sibille, PhD S. Someya, PhD

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