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CRISTAIS DE DIPÉPTIDOS POTENCIAIS APLICAÇÕES EM ADSORÇÃO E PERMEAÇÃO SELECTIVA

This paper discusses the potential applications of peptide-based nanoporous crystals in adsorption and selective permeation processes, with a focus on their high pore density, adjustable pore size, and ability to sustain and exchange guest molecules. The study also explores their remarkable hydrogen storage capacity and potential use in methane purification from CO2. The crystal's thermal and mechanical stability, as well as their excellent selectivity and permeability, make them candidates for applications in gas sensor devices and composite membranes.

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CRISTAIS DE DIPÉPTIDOS POTENCIAIS APLICAÇÕES EM ADSORÇÃO E PERMEAÇÃO SELECTIVA

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  1. CRISTAIS DE DIPÉPTIDOS POTENCIAIS APLICAÇÕES EM ADSORÇÃO E PERMEAÇÃO SELECTIVA LUÍS GALES Encontro Ciência 2010

  2. Amyloid fibrils are hallmarks of a number of degenerative diseases. • They are highly-ordered structures and easy to reproduce in vitro.

  3. Beta amyloid main constituent of amyloid plaques in the brains of Alzheimer's disease patients H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH Costa et al. FEBS Letters (2008)

  4. H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

  5. Beta amyloid

  6. H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

  7. Dipeptides form nanoporous crystals

  8. Nanotube formation by dipeptides • diameter of the channels can be regulated. • pore core environment can be set hydrophilic or hydrophobic.

  9. Nanotube formation by dipeptides dp = 9.2 Å dp = 4.9 Å dp = 3.7 Å • diameter of the channels can be regulated. • pore core environment can be set hydrophilic or hydrophobic.

  10. Nanotube formation by dipeptides LS crystals filled empty filled Acetonitrile I2 • ability to sustain and exchange guest molecules

  11. Nanotube formation by dipeptides Urea crystals • ability to sustain and exchange guest molecules

  12. Nanotube formation by dipeptides Thermo-gravimetric analysis LS crystals FF crystals • thermal and mechanical stability

  13. Peptide based nanoporous crystals MATERIAL PROPERTIES • extremely high pore density • single pore size • - diameter can be regulated. • - set hydrophilic or hydrophobic environment . • very high surface area • ability to exchange guest molecules • thermal and mechanical stability

  14. Adsorption

  15. Adsorption Methane purification from CO2 Remarkable hydrogen storage capacity

  16. Table 1. Dipeptide crystals permeabilities and selectivities towards He, O2, N2 and Ar. [a] calculated from the crystal structure / reported by[4] based on He pycnometry. [b] calculated from single-crystal monocomponent permeation experiments. [c] the minimum permeate flow rate that can be accurate measured in the setup is ~0.0005 mm3/h which corresponds to a permeability of ~0.25 barrer (AA crystals) and of ~20 barrer (VI crystals).

  17. Figure 4. Adsorption isotherms of argon (squares), nitrogen (close circles) and oxygen (open circles) in LS, VI and AA at 295K.

  18. Excelent selectivity, Very good permeability CARBON NANOTUBES Science,2006

  19. In conclusion, • separations of practical significance are primarily obtained by size exclusion • AA crystals show extremely high O2/N2 selectivities • potential applications in the fabrication of gas sensor devices or composite membranes

  20. Financial support: • PTDC/CTM/64191/2006 • REEQ/564/BIO/2005 • SFRH/BD/43821/2008.

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