1 / 7

Conformational change

Figure 6.19 Allosteric Regulation of Enzymes. Conformational change. Inactive form. Active form. The enzyme switches back and forth between the two forms. They are in equilibrium. Figure 6.19 Allosteric Regulation of Enzymes. Allosteric site. Active site. Conformational change.

lona
Download Presentation

Conformational change

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Figure 6.19 Allosteric Regulation of Enzymes Conformational change Inactive form Active form The enzyme switches back and forth between the two forms. They are in equilibrium.

  2. Figure 6.19 Allosteric Regulation of Enzymes Allosteric site Active site Conformational change Inactive form Active form

  3. Figure 6.19 Allosteric Regulation of Enzymes Catalytic subunit Regulatory subunit Allosteric regulation Inactive form When the enzyme is in its inactive form, the allosteric sites on the regulatory subunits can accept inhibitor.

  4. Figure 6.19 Allosteric Regulation of Enzymes Catalytic subunit Regulatory subunit Allosteric inhibitor Allosteric regulation Inactive form

  5. Figure 6.19 Allosteric Regulation of Enzymes Allosteric regulation Active form When the enzyme is in its active form, the active sites on the catalytic subunits can accept substrate.

  6. Figure 6.19 Allosteric Regulation of Enzymes Substrate Cooperativity Once a site is filled with a substrate or inhibitor, binding at a second site of the same type is favored.

  7. Figure 6.19 Allosteric Regulation of Enzymes No product formation Product formation Cooperativity

More Related