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Workshop on Atrial Fibrillation

Workshop on Atrial Fibrillation. Group 6. Atrial Fibrillation. The most common type of arrhythmia (irregular heartbeat) In AF, atria contract very fast and irregularly. Atria get pooled by blood. Blood not being able to go into ventricles completely.

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Workshop on Atrial Fibrillation

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  1. Workshop on Atrial Fibrillation Group 6

  2. Atrial Fibrillation • The most common type of arrhythmia (irregular heartbeat) • In AF, atria contract very fast and irregularly. • Atria get pooled by blood. • Blood not being able to go into ventricles completely. • Consequently, atria and ventricles do not work together. • The heart’s electrical signals do not begin in the SA node. • Signals begin in another part of the atria or in pulmonary veins and they don’t travel normally. • The amount of blood pumped by ventricles to the body depends on atrial beats.

  3. Spiral Waves • Interesting patterns seen in many experiments. Example: Belousov- Zhabotinsky • Usually rotate without changing their shapes • The tip traces out a perfect circle • After getting destabilized, they either drift or meander.

  4. Inward meandering

  5. Outward meandering

  6. Drifting Spiral Waves

  7. Parameters GNa – Conductance for fast Na+ channel kNaCa – Current for Na+/Ca2+ exchanger Na+/Ca2+ exchanger- An antiport, where three Na+are brought in for one Ca2+, when the membrane potential is negative and when the cell is depolarized, Na+ leaves and Ca2+ enters. GNavskNaCa

  8. Spiral Wave of Day 1 GNa Maximal INa conductance KNaCa Maximal INaCa

  9. Path of Day 1 GNa Maximal INa conductance Maximal INaCa KNaCa

  10. Spiral wave Day 2 GNa Maximal INa conductance Maximal INaCa KNaCa

  11. Path of Day 2 GNa Maximal INa conductance Maximal INaCa KNaCa

  12. Day 1 VS. Day 2Wave Comparison

  13. Day 1 VS Day 2Trajectory Comparison

  14. Conclusions: • Spiral waves are influenced by the concentration of Ions. • Different shape of the spirals depending on which concentration is changed first. • Low concentration of Sodium Calcium exchanger and high concentration of Sodium produces trajectories that are more chaotic. • High Sodium-Calcium concentration and low Sodium concentration produces spiral trajectories that are tight.

  15. Acknowledgement • Nancy Griffeth • Flavio Fenton • Robert Gilmour • Bard Ermentrout • AronWolinetz • Charles Beard • Rachel Spratt • All participants

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