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Training. Essential nutrients for your health. What is a Food Supplement?. Content. Key message Introduction Product information Key benefits Target group Composition & intake Ingredients S exual desire Low sexual desire Female sexual dysfunction Good to know

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Training

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  1. Training Essential nutrients for your health

  2. Whatis a Food Supplement?

  3. Content • Key message • Introduction • Product information • Key benefits • Target group • Composition & intake • Ingredients • Sexual desire • Low sexual desire • Female sexual dysfunction • Good to know • Complementary treatment • References

  4. 1. Key message • In the 21st century, women have to face many challenges every single day. • They often have stressful and demanding days resulting in tiredness and fatigue which can influence the entire life of a woman, including her sexual desire. • 40 % of the women in the United States report of low libido.1The exact causes are very divers and differ from woman to women. • is a special nutrient combination to support female libido and overall health. • Reduces tiredness – for more fun and energy. • May give your relationship new excitement.

  5. 2. Introduction • It is not unusual for couples to have a disparity in their sex drives. • More often than not, in a heterosexual relationship, it's the woman who has the lower libido. This can be distressing for both partners and even put the relationship at risk if it can't be resolved. 2 • Women‘s sexual desiresnaturallyfluctuateover the years. 2 • Highs and lows commonly coincide with the beginning or end of a relationship, with major life changes, such as pregnancy, menopause or illness or emotional or psychological problems. But also some medications used for mood disorders can cause low libido in women. 2 • The good news is that identifying the root cause of low libido in women can lead to an effective treatment.

  6. 3. Product information Effectivenutrientcombinationforwomen

  7. 3. Product information Effectivenutrientcombinationforwomen

  8. 4. Key benefits • libidolady Denk is an ideal combinationforboostingfemalelibido, enhancing sexual pleasureandincreasingenergylevels in women.. • libidolady Denk contains high-quality natural plant extractsandvitaminsfor a normal energy-yieldigmetabolism. • libidolady Denk is not tailoredfor immediate short-term effects after intakea continousintakefor at least 4 weeksisrecommendedforspontaneousfunandperformance. • Easy administration – onlyonecapsule a dayforenduringpleasure.

  9. 5. Target group All womenwhowanttoboosttheirlibido Stressedandexhaustedwomen Elderlywomen before, duringand after menopause

  10. 6. Composition & intake INGREDIENTS *nodailyrequirementdataavailable • INTAKE • The recommendedintakeis1 capsule per daywithplenty of fluid. • To betakencontinously and regulary for at least 4 weeks .

  11. 7. Ingredients Vitamin C • Vitamin C contributes to normal energy-yielding metabolism, normal psychological function, to the reduction of tiredness and fatigue and to the reduction of oxidative stress.3 • Population research suggests that higher intake of dietary vitamin C is associated with improved physical performance and muscle strength. 4 • Also, taking vitamin C seems to improve maximal oxygen uptake during exercise. 5 • Through its positive influence on energy-yielding metabolism and physical performance, vitamin C may be able to boost libido and sexual pleasure.

  12. 7. Ingredients Vitamin B6 • Vitamin B6 contributes to normal energy-yielding metabolism, to normal functioning of the nervous system, to normal red blood cell formation, to the reduction of tiredness and fatigue and to normal psychological function. 3 • Vitamin B6 is an essential co-factor in fatty acid metabolism that contributes to the regulation of hormonal activity because it has a role in controlling the action of hormones. 3 • There is some evidence that taking vitamin B6 orally can improve symptoms of premenstrual syndrome (PMS) such as breast pain or tenderness (mastalgia) and PMS-related depression in some patients. 6, 7 •  Through its positive influence on energy-yielding metabolism and physical performance, vitamin C may be able to boost libido and sexual pleasure.

  13. 7. Ingredients Folicacid • Folic acid contributes to normal blood formation, to the reduction of tiredness and fatigue and to normal psychological function. 3 •  Folic acid improves psychological and emotional causes for low libido in women and may thereby boost sex drive and sexual pleasure.

  14. 7. Ingredients Damianaextract • Damianais a mexican shrub with aphrodisiac properties. It has been described as a sexual stimulant for about 300 years. 8 • The applicable parts of damiana are the leaf and stem. Damiana constituents include as many as 35 compounds including flavonoids and terpenoids. 9 • Animal research underlines that damiana leaf extract can improve sexual motivation and sexual performance in rats. 10 •  The exact mechanism of damiana’s sexual effect is still unclear. 11There is scientific evidence that the effect is due to an increase in genital blood flow and hence an increase in genital sensation. Moreover, damiana seems to address a psychological cause of low libido (psychological causes) by reducing depressive mood.

  15. 7. Ingredients Ginkgo biloba • Ginkgo biloba is a native tree from China used for pharmaceutical purposes. 8 • Contains flavonoids and terpenoids as active substances. Flavonoids have antioxidant and free radical scavenging properties that might benefit the central nervous system and vascular conditions by improving blood circulation. 8 • Ginkgo leaf seems to improve blood flow to capillaries throughout the body including in the CNS, eyes, ears, extremities and the genital region. 8  The increased blood flow to the genital region due to ginkgo biloba may contribute to increased genital sensation, libido boost and enhanced sexual response.

  16. 7. Ingredients Caffeine • Caffeine occurs naturally in more than 60 plants. 12 • It stimulates heart rate, muscle function, blood pressure and nervous system and provides a short-time relief of fatigue. 12 • Moreover, caffeine has a positive effect on cognitive and physical function, mood and energy.12  Caffeine provides an energetic, efficient and self-confident feeling that supports a positive attitude which in turn supports sexual arousal. 12

  17. 8. Sexual desire FACTORS INFLUENCING FEMALE SEXUAL DESIRE (1/2) 13 Female sexuality and sexual function, including a woman’s ability to orgasm, is very complex and influenced by both physical and psychosocial factors: PSYCHOSOCIAL FACTORS Relationship quality  Association with satisfaction with sexual relationship and partner 1 Emotional health  Psychological disorders such as depression, but also issues like self esteem or body image, influence sexual response 2 Socialperceptionoffemalesexuality  Women living in cultures which expect women to enjoy sex are more likely to orgasm than those living in cultures that don’t expect women to enjoy sex 3

  18. 8. Sexual desire FACTORS INFLUENCING FEMALE SEXUAL DESIRE (2/2) 13 Female sexuality and sexual function, including a woman’s ability to orgasm, is very complex and influenced by both physical and psychosocial factors: DEMOGRAPHICAL, PHYSICAL AND HORMONAL FACTORS Age  Higher rates of anorgasmia amongst older women (e.g. due to reduced self esteem loss of partner, hormonal changes,…) 1 Oestrogen  Declining levels of oestrogen which occur with menopause have been identified as the main cause of changes in genital sensations and genital blood flow 2 Testosterone  Testosterone levels change naturally throughout the menstrual cycle. Low levels of testosterone are associated with decreased sexual arousal and orgasm. 3 Medical conditions ad medications  Many medical conditions and some medications can lead to changes in a woman’s orgasmic experience, including reduced frequency of orgasm, 4

  19. 9. Low sexual desire • WHAT IS LOW SEXUAL DESIRE? 14, 15,16 • The definition of "low libido" may be different for each person. In general, low sexual desire is a lasting lack of desire for or interest in sex. • There is no single standard of sexual desire and desire differs not only from person to person but also in the same person over one's lifespan. • One of the most common sexual complaints among couples is a disparity in sexual desire. Sexual desire and responsiveness normally differ between men and women. Men are more readily biologically aroused than women and, for them, desire is tied tightly to physiologic arousal.  • Low sexual desire becomes a diagnosable condition only when it diminishes the quality of one’s life and creates distress, or a disparity arises in the sex drive of partners, evolving into a matter of unresolved contention in the relationship.

  20. 9. Low sexual desire CAUSES FOR LOW LIBIDO 14

  21. 9. Low sexual desire DEFINITION OF MENOPAUSE 17, 18 • Menopause is a natural biological process. It is defined as occurring 12 months after the last menstrual period and marks the end of menstrual cycles. • Menopause results from the natural decline of reproductive hormones. • Menopause occurs in women in general around the age of 50 years, sometimes earlier. SYMPTOMS OF MENOPAUSE 17, 18 • Irregular periods • Hot flashes • Night sweats • Mood changes and decreased libido • weight gain and slowed metabolism • Chills • Sleep problems • Headache • Thinning hair and dry skin

  22. 9. Low sexual desire THE ROLE OF WOMENS’ SEX HORMONES AND THE EFFECT OF MENOPAUSE AND AGING ON ITS FUNCTIONS 19

  23. 10. Female sexual dysfunction WHAT IS FEMALE SEXUAL DYSFUNCTION? 14 • Persistent, recurrent problems with sexual response, desire, orgasm or pain – that distress or strain the relationship are known medically as female sexual dysfunction • Female sexual dysfunction can occur at any stage of life. It can be lifelong or be acquired later in life. It can occur in certain sexual situations or in all sexual situations. • Sexual response involves a complex interplay of physiology, emotions, experiences, beliefs, lifestyle and relationships  Disruption of any component can affect sexual desire, arousal or satisfaction. • When a woman experiences a significant decrease in interest in sex that is having an effect on her life and is causing distress then it is considered a problem with low sexual desire.

  24. 10. Female sexual dysfunction COMPONENTS OF FEMALE SEXUAL DYSFUNCTION 14 1 2 3 is a special nutrient combination to support female libido and overall health.

  25. 11. Good to know CONDITIONS WHERE LIBIDO LADY DENK SHOULD NOT BE TAKEN 20, 21, 22 • If someone has a known allergy or sensitivity to any of the contained ingredients. 1 • During pregnancy. • There are some hints that Ginkgo biloba might • increase the disposition to haemorrhage. • prolong bleeding time if taken around the time of labor and delivery. • adversely affect pregnancy outcome. • Avoid using during pregnancy. 2 • During lactation. • Insufficient reliable information available during lactation concerning safety of Ginkgo biloba. • Avoid using during lactation precautionary. 3

  26. 11. Good to know CONSULTATION OF A DOCTOR OR PHARMACIST IS ADVICED23, 24, 25, 26, 27, 28 • When someone suffers from pathologically increased bleeding tendency or during concomitant intake of certain anticoagulants (e.g. Warfarin, Clopidogrel, Phenprocoumon). • There are studies that suggest that Ginkgo biloba • inhibits platelet aggregation. • when taken concurrently with warfarin increases the risk of a bleeding. • Until more is known, monitor blood clotting closely in patients taking ginkgo. 1 • There are sporadic hints that preparations containing Ginkgo biloba could increase bleeding tendency therefore libido lady Denk should be stopped as a precaution before operations. 2 • . In epileptic patients or patients prone to seizures. 3 In case of chronic illnesses or chronic drug intake. 4

  27. 12. Complementary treatment The counterpartformen + libido lady Denk is a special nutrient combination to support female libido and overall health. • man active Denk is a food supplement tailored for men to be strong and sexually active. • Nutrient combination of high quality plant extracts, L-arginine, caffeine, vitamins and minerals for natural libido and energy boost.

  28. 13. References 1Shifren JL (2008): Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol. 112(5): 970–978. 2 Mayo Clinic (2018): Low sex drive in women. Symptoms and causes. https://www.mayoclinic.org/diseases-conditions/low-sex-drive-in-women/symptoms-causes/syc-20374554 3European Commission (2012): Commission regulation (EU) No 432/2012 4Cesari M (2004): Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J ClinNutr. 79: 289-294. 5Suboticanec-Buzina K (1984): Vitamin C status and physical working capacity in adolescents. Int J VitamNutr Res. 54(1): 55-60. 6Whelan AM (2009): Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Can J ClinPharmacol. 16(3): e407-e429. 7Macdougall M (2000): Poor-quality studies suggest that vitamin B6 use is beneficial in premenstrual syndrome. West J Med. 172(4): 245. 8Rowland DL (2003): Review of Plant-Derived and Herbal Approaches to the Treatment of Sexual Dysfunctions. J Sex Marital Ther. 29(3): 185-205 9Zhao J (2007): Phytochemical investigation of Turneradiffusa. J Nat Prod. 70: 289-292. 10Arletti R (1999): Stimulating property of Turneradiffusa and Pfaffiapaniculata extracts on the sexual-behavior of male rats. Psychopharmacology (Berl). 143: 15-19.

  29. 13. References 11Natural Medicines™ (2018):Damiana. 12Bertil B (1999): Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use, Pharmacol Rev. 51(1): 83-133. 13VirtualMedicalCentre (2010): Female orgasm. https://www.myvmc.com/lifestyles/female-orgasm/ 14Mayo Clinic (2018): Low sex drive in women. Diagnosis & treatment. http://www.mayoclinic.org/diseases-conditions/low-sex-drive-in-women/basics/treatment/con-20033229 15Rider‘s Digest (2018): Understanding hypoactive sexual desire disorder. http://www.readersdigest.co.uk/health/wellbeing/understanding-hypoactive-sexual-desire-disorder 16Psychology Today (2018): Low Sexual Desire. HypoactiveSexualDesire. https://www.psychologytoday.com/us/basics/low-sexual-desire 17National Institute of Aging (2017): What are the Signs and Symptoms of Menopause? https://www.nia.nih.gov/health/publication/menopause-time-change/signs-menopausal-transition 18Mayo Clinic (2017): Menopause. Symptoms & Causes. https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 19 North American Menopause Society (2010): Changes in Hormone Levels. https://www.menopause.org/for-women/sexual-health-menopause-online/changes-at-midlife/changes-in-hormone-levels 20Mayo Clinic (2015): Ginkgo biloba. 21Dugoua JJ (2006): Safety and efficacy of Ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J ClinPharmacol. 13 (3): 277-284.

  30. 13. References 22Therapeutic Research Center (2017): Ginkgo. Natural Medicines™. 23 Heck AM (2000): Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 57 (13): 1221-1227. 24Kudolo GB (2002): Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Tyxpe 2 diabetic subjects. Thromb Res. 108 (2-3): 151-160. 25Stoddard GJ (2015): Ginkgo and Warfarin Interaction in a Large Veterans Administration Population. AMIA AnnuSymp Proc. 1174-1183. 26Gaudineau C (2004): Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. BiochemBiophys Res Commun. 318 (4): 1072-1078. 27Miwa H (2001): Generalized convulsions after consuming a large amount of ginkgo nuts. Epilepsia. 42 (2): 280-281. 28Gregory PJ (2001): Seizure associated with Ginkgo biloba. Ann Intern Med. 123 (4): 344.

  31. Join Denk Pharma! Our contributions to keeping you* healthy: • affordable pharmaceuticals for your therapy • German high premium quality for tablets, sachets, • packaging, studies, consultation, availability, support, etc… • raise awareness by conducting Check Up Days (blood glucose, • blood pressure, cholesterol and triglyceride) • constantly enhancing the product portfolio *patients, doctors, pharmacists, sales reps

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