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U06- 23362

U06- 23362. #944696920 ATN 1 year ago with recovery but now proteinuria with DM ?other diagnoses. 49y Aboriginal male with DM dxd in 1989 and HT dxd in 2003 Several admissions to ER with high creatinines which then resolved, ? From volume depletion/ACE inhibition, elevated CKs

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U06- 23362

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  1. U06-23362 #944696920 • ATN 1 year ago with recovery but now proteinuria with DM • ?other diagnoses

  2. 49y Aboriginal male with DM dxd in 1989 and HT dxd in 2003 Several admissions to ER with high creatinines which then resolved, ? From volume depletion/ACE inhibition, elevated CKs Creatinine oscillating High grade proteinuria, 3+ since at least 2004, PCR of 707 on July 2006. HbA1c 10.1 in 2004, 7.2 in Nov 2006 UA –tr- 1+ blood, 3+ protein, some dysmorphic rbc, no rbc casts, some granular casts C3, C4 normal, ANA, ANCA, anti GBM, SPEP, Hep B, Hep C negative Albumin 27, Cholesterol 7.14 → CK of 900 on lipitor! Renal US – normal kidneys BP shot up in October, requiring 4-6 meds for control, c/o puffy face and periodic pedal edema MRA – no renal artery stenosis

  3. Creatinine ER, ? dehydration ER, ? dehydration Renal clinic Urine PCR BP 194/107 BP 146/87 BP 117/80 BP 121/72 BP 116/86

  4. IF • IgG- Mild linear GBM staining, a common finding in diabetes. • IgA- Mild to moderate mesangial staining. • IgM- Mild mesangial staining. Mild vascular staining. • C3- Mild to moderate mesangial staining. Moderate vascular staining. • C1q- Moderate mesangial staining. Moderate vascular staining. • Kappa and Lambda-Negative. • Fibrinogen- Mild interstitial staining. • Albumin- Mild to moderate linear GBM and TBM staining, a common finding in diabetes. Moderate hyaline droplet change in tubular cytoplasm.

  5. IgG

  6. IgA

  7. IgM

  8. IgM

  9. C3

  10. C3

  11. C1q

  12. C1q

  13. fibrinogen

  14. albumin

  15. albumin

  16. albumin

  17. EM • Will be ready in the coming weeks

  18. DiagnosisRenal Biopsy: • Diffuse diabetic glomerulosclerosis with superimposed focal proliferative IgA nephropathy with occasional crescent formation.

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