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Frédéric Amant MD PhD UZLeuven, Belgium Antoni Van Leeuwenhoek, Amsterdam, The Netherlands

Outcome of 129 children after antenatal exposure to cancer treatment: Results of a case-control study from the International Network on Cancer, Infertility and Pregnancy registry. Frédéric Amant MD PhD UZLeuven, Belgium Antoni Van Leeuwenhoek, Amsterdam, The Netherlands. Study design.

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Frédéric Amant MD PhD UZLeuven, Belgium Antoni Van Leeuwenhoek, Amsterdam, The Netherlands

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  1. Outcome of 129 children after antenatal exposure to cancer treatment: Results of a case-control study from the International Network on Cancer, Infertility and Pregnancy registry Frédéric Amant MD PhD UZLeuven, Belgium Antoni Van Leeuwenhoek, Amsterdam, The Netherlands

  2. Study design 129 studychildrenborn tomotherswithcancerduringpregnancy 129 control childrenborn afteranuncomplicatedpregnancyand delivery 1:1 matched 89 chemotherapy (+ surgery) 4 radiotherapy (+ surgery) 7 chemotherapy + radiotherapy (+ surgery) 1 trastuzumab 1 interferon-β 13 surgery only 14 no treatment during pregnancy 96 chemotherapy 11 radiotherapy

  3. Methods

  4. Postnatal growth Males Females Length (cm) Length (cm) Weight (kg) Weight (kg) Head circumference (cm) Head circumference (cm) Study group Control group

  5. General health • Incidence of medicalproblems • Needforsurgery or medical care comparablebetweenstudyand control group

  6. Cognitiveoutcome Study group Control group ------

  7. Cognitive outcome and chemo cycles

  8. Cognitive outcome and prematurity Study group X ---- Control group

  9. Acknowledgements Fund for Cancer in Pregnancy

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