1 / 19

Umbilical Cord Tissue Presentation

Umbilical Cord Tissue Presentation. Stem Cell Cryobank in association with South Florida Bone Marrow Stem Cell Transplant Institute August 2013. Umbilical Cord Tissue.

louisa
Download Presentation

Umbilical Cord Tissue Presentation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Umbilical Cord Tissue Presentation Stem Cell Cryobank in association with South Florida Bone Marrow Stem Cell Transplant Institute August 2013

  2. Umbilical Cord Tissue • This is a cross section of the umbilical cord, showing an umbilical cord vein and two umbilical cord arteries inside the cord. These blood vessels are surrounded by Wharton’s Jelly, which may also be called cord tissue, and contains mesenchymal stem cells.

  3. Cord Blood & Cord Tissue • Cord blood is located in the placenta and is collected from a vein in the umbilical cord. Cord tissue and cord blood are separate sources of stem cells. The two sources of cells are processed and stored separately, each having no impact on the other. Together they producer higher volumes of stem cells which increase their ability to be utilized.

  4. A 6x Yield Increase with Cord Tissue • Up to 6-fold increase in engrafted cells for transplant when cord blood and cord tissue stem cells are combined in a pre-clinical setting. • Taghizadeh RR, Pollok KE, Betancur M, et al. Wharton’s jelly derived mesenchymal stem cells: regenerative medicine beyond umbilical cord blood. Presented at: First Meeting of the Placenta Stem Cell Society (IPLASS). From Fetomaternal Tolerance to Immunomodulary Properties of Placenta-Derived Cells in Cell Therapy [poster abstract]; October 3–6, 2010; Brescra, Italy. [As measured by CD45+]

  5. Cord Blood Tissue Safety • As with cord blood, the collection process for Cord Lining is fast, easy, and painless. First, your baby’s umbilical cord is clamped and cut, and the cord blood is collected. Your health care professional will then collect 5”-10” of the umbilical cord which contains the cord lining and place it into the protective cup provided in your Stem Cell Cryobankcollection kit.

  6. Freezing Cord Blood Tissue • The freezing process for cord lining cells is similar to the method used to freeze cord blood cells. After the umbilical cord is collected, the cord lining is cleaned and processed, and then it is put in a cryopreservation media, and frozen to maximize the preservation of cells. This is done in an FDA registered laboratory.

  7. Still Need to Bank Cord Blood? • Yes, you still need to bank your cord blood. All currently FDA-approved uses of cord blood involve stem cells from cord blood. Cord blood is a proven source of stem cells and the first choice by doctors to treat over 80 diseases. With over 30,000 cord blood transplants in the past 20+ years, cord blood is the obvious first choice of cells to bank.

  8. Cord Blood Tissue Collection Kit • Our kits are designed to keep your baby’s Cord Blood and Cord Lining safe and protected from environmental conditions, while being transported back to our laboratory for processing. Our collection kit conforms to the highest industry standards, to ensure that your cord blood and tissue reaches us in the best possible condition, so that we can store the most viable cells and cell types. We have worked hard to make our kit as light as possible.

  9. Cord Blood Treatable Diseases • * MoiseK Jr. Umbilical cord stem cells. Obstet Gynecol. 2005;106(6):1393-1407. Around 25 years ago, the first human transplant using umbilical cord blood stem cells was performed. At the time, only one disease was treatable using cord blood stem cells. Today, cord blood stem cells can be used in the treatment of nearly 80 diseases* and the list continues to develop. So what’s behind this growing number? Science.

  10. Cord Blood Treatable Diseases • CancersAcute lymphoblastic leukemia (ALL)  • Acute myeloid leukemia (AML)  • Burkitt's lymphoma  • Chronic myeloid leukemia (CML)  • Juvenile myelomonocytic leukemia (JMML)  • Non-Hodgkin's lymphoma Hodgkin's lymphoma  • Lymphomatoidgranulomatosis • Myelodysplastic syndrome (MDS)  • Chronic myelomonocytic leukemia (CMML) • Bone Marrow Failure Syndromes • Amegakaryocytic thrombocytopenia  • Autoimmune neutropenia (severe)  • Congenital dyserythropoietic anemia  • Cyclic neutropenia  • Diamond-Blackfan anemia  • Evan's syndrome  • Fanconi anemia  • Glanzmann's disease  • Juvenile dermatomyositis • Kostmann's syndrome  • Red cell aplasia  • Shwachman syndrome  • Severe aplastic anemia  • Congenital sideroblastic anemia  • Thrombocytopenia with absent radius (TAR syndrome)  • Dyskeratosiscongenita • Blood Disorders • Sickle-cell anemia (hemoglobin SS)  • HbSC disease  • Sickle βo Thalassemia  • α-thalassemia major (hydropsfetalis)  • β-thalassemia major (Cooley's anemia)  • β-thalassemia intermedia • E-βo thalassemia  • E-β+ thalassemia

  11. Cord Blood Treatable Diseases • Metabolic Disorders • AdrenoleukodystrophyGaucher's disease (infantile)  • Metachromatic leukodystrophy • Krabbe disease (globoid cell leukodystrophy)  • Gunther disease  • Hermansky-Pudlak syndrome  • Hurler syndrome  • Hurler-Scheie syndrome  • Hunter syndrome  • Sanfilippo syndrome  • Maroteaux-Lamy syndrome  • Mucolipidosis Type II, III  • Alpha mannosidosis • Niemann Pick Syndrome, type A and B  • Sandhoff Syndrome  • Tay-Sachs Disease  • Batten disease (inherited neuronal ceroidlipofuscinosis) • Lesch-Nyhandisease • Immunodeficiencies • Ataxia telangiectasia  • Chronic granulomatous disease  • DiGeorge syndrome  • IKK gamma deficiency  • Immune dysregulationpolyendocrineopathy • X-linked Mucolipidosis, Type II  • Myelokathexis X-linked immunodeficiency  • Severe combined immunodeficiency  • Adenosine deaminase deficiency  • Wiskott-Aldrich syndrome  • X-linked agammaglobulinemia • X-linked lymphoproliferative disease  • Omenn's syndrome  • Reticular dysplasia  • Thymic dysplasia  • Leukocyte adhesion deficiency • Other • Osteopetrosis • Langerhans cell histiocytosis • Hemophagocyticlymphohistiocytosis

  12. Potential Benefits It's estimated that 1 in 3 people may benefit from regenerative medicine therapy for a range of illnesses, including: stroke, cerebral palsy, spinal cord injury, and type 1 diabetes. Harris DT. Cord blood stem cells: a review of potential neurological applications. Stem Cell Rev. 2008;4:269-274. Epub August 5, 2008

  13. Cord Blood Tissue Research • Stem cells from cord tissue have the power to regenerate other cells, as well as, structural and connective tissue: • Liver fibrosis • Lung cancer • Parkinson’s disease • Rheumatoid arthritis  • Sports injuries (cartilage) • Type 1 diabetes

  14. Cord Blood Tissue Published Articles • Pre-clinical Cord Tissue Stem Cell Research for Parkinson's Disease • Fu YS, Cheng YC, Lin MY, et al. Conversion of human umbilical cord mesenchymal stem cells in Wharton’s jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells. 2006;24(1):115-124. Epub 2005 Aug • Pre-clinical Cord Tissue Stem Cell Research for Rheumatoid Arthritis • Liu Y, Mu R, Wang S, et al. Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther. 2010;12(6):R210. • Pre-clinical Cord Tissue Stem Cell Research for Stroke • Ding DC, Shyu WC, Chiang MF, et al. Enhancement of neuroplasticity through upregulation of ß1-integrin in human umbilical cord-derived stromal cell implanted stroke model. Neurobiol Dis. 2007;27(3):339-353. Epub 2007 Jun 18. • Pre-clinical Cord Tissue Stem Cell Research for Type 1 Diabetes • Anzalone R, Lo Iacono M, Loria T, et al. Wharton’s jelly mesenchymal stem cells as candidates for beta cells regeneration: extending the differentiative and immunomodulatory benefits of adult mesenchymal stem cells for the treatment of type 1 diabetes. Stem Cell Rev. October 23, 2010. [Epub ahead of print.] • Pre-clinical Cord Tissue Stem Cell Research for Liver Fibrosis • Tsai PC, Fu TW, Chen YM, et al. The therapeutic potential of human umbilical mesenchymal stem cells from Wharton’s jelly in the treatment of rat liver fibrosis. Liver Transpl. 2009;15(5):484-495. • Pre-clinical Cord Tissue Stem Cell Research for Lung Cancer • Maurya DK, Doi C, Kawabata A, et al. Therapy with un-engineered naïve rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcinoma. BMC Cancer. 2010;10:590. • Pre-clinical Cord Tissue Stem Cell Research for Sports Injuries (cartilage) • Wang L, Tran I, Seshareddy K, et al. A comparison of human bone marrow-derived mesenchymal stem cells and human umbilical cord-derived mesenchymal stromal cells for cartilage tissue engineering. Tissue Eng. 2009;15(8)(pt A):2259-2266.

  15. Competitive Pricing (standard pricing) Here’s how Stem Cell Cryobank compares with other companies for cord blood and cord tissue collection and storage services: ViaCordCBRStem Cell Cryobank Cord Blood Collection $1895 $1995 $1850 Annual Storage $125 $130 $130 Cord Tissue Collection $1445 $900 $889 Annual Storage $150 $130 $130 Total $3340 $2895$2739 BEST VALUE * All services include 1st year’s storage included in the Cord Blood and Cord Blood Tissue Collection Fee.

  16. ABOUT THE INSTITUTE • South Florida Bone Marrow/Stem Cell Transplant Institute: • • Our Stem Cell Transplant Director has more than 30 years of • experience in stem cell collection, storage and transplantation. • • Totally outpatient stem cell transplantation for many cancers have been performed at the Institute for over a decade. • • The Institute is a global pioneer in regenerative medicine. • • A leader in healthy adult stem cell collection and storage. • • Specializes in both disease research and patient treatment

  17. Cancer & other major diseases are waging war against our health everyday… The time to fight back is now Collect and Store Your Baby’s Cord Blood Tissue Today.

  18. Contact The Institute Stem Cell Cryobank South Florida Bone Marrow/ Stem Cell Transplant Institute 10301 Hagen Ranch Road, Suite 600 Boynton Beach, FL 33437 Telephone: 561-752-5522 Fax: 561-752-5446 Email: info@bmscti.org Email: info@stemcellcryobank.com Website: www.bmscti.org Website: www.stemcellcryobank.com

  19. Widescreen Test Pattern (16:9) Aspect Ratio Test (Should appear circular) 4x3 16x9

More Related