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Construction of Stable Nucleic Acid Nanostructures

Construction of Stable Nucleic Acid Nanostructures. Anna Feng Dr. James Canary Johan Guillanme NYU Department of Chemistry. Introduction.

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Construction of Stable Nucleic Acid Nanostructures

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  1. Construction of Stable Nucleic Acid Nanostructures Anna Feng Dr. James Canary Johan Guillanme NYU Department of Chemistry

  2. Introduction • The goal of this project is to construct a DNA that will be modified to stay rigid in many extreme conditions such as acidity or basicity, and heat. • The result of this project can be applied to the development of new drugs (antisense) and the advancement of nanotechnology.

  3. Key Terms • Nanostructure: A material whose size ranges from 1 to 99 nanometers. • Nanotechnology: branch of science that deals with materials smaller than 100 nanometers. • Nucleic Acid: Either DNA and RNA. Nucleic acids are used in the cell as storage of genetic information. • In our project, nucleic acids will be used to develop drugs and advance nanotechnology.

  4. Project Description

  5. Materials and Methods • The method used throughout this project is organic synthesis. • My major contribution has been the purification of then compounds using Thin Layer Chromatography and Column Chromatography.

  6. Results • The structures of the compounds made in this project were verified using Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy. • The synthesis of the compounds has been successful.

  7. Conclusion • The results of the project are promising. It can eventually be used in medicine, pharmacology, and nanotechnology.

  8. Acknowledgment Dr. James Canary Johan Guillanme Dr. Sat Harlem Children Society NYU Department of Chemistry

  9. Bibliography • Zhu, L., et al. Reaction of N3-Benzoyl-3’,5’-O-(Di-tertbutylsilanediyl)Uridine with hindered Electrophiles: Intermolecular N3 to 2’-O Protecting group transfer. Nucleoside, Nucleotides, & Nucleic Acid, 2002, 21, 723. • Urban, E.; Noe, C. R. Structural Modification of Antisense Oligonucleotide. Il Farmaco, 2003, 58, 243. • Werner, D.; Helmut, B.; Noe, R.C. Investigations on the influence of 2’-O-alkyl Modifications on the Base Pairing Properties of Oligonucleotides. Pharmaceutica Acta Helvetiae, 1998, 73, 3. • Seeman, N. Biochemistry and Structural DNA Nanotechnology: An Evolving Symbiotic Relationship. Biochemistry, 2003, 42, 7260. • Zhu, L., et al. Nylon/DNA: Single-Stranded DNA with Covalently Stitched Nylon Lining. J. Am. Chem. Soc., 2003, 125, 10178-10179. • Seeman, N. C. DNA Engineering and its Application to Nanotechnology. TIBTECH, 1999, 17, 437. • Seeman, N. C. Nucleic Acid Nanostructure and Topology. Angew. Chem. Int. Ed., 1998, 37, 3220-3238. • Poulin-Kerstien, A.; Dervan B. P. DNA-Templated Dimerization of Hairpin Polyamides. J. Am. Chem. Soc., 2003, 125, 15811-15821.

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