WHICAP Washington Heights/Hamilton Heights-Inwood Columbia Aging Project

1. WHICAPWashington Heights/Hamilton Heights-Inwood Columbia Aging Project Jennifer J. Manly, PhD Laura B. Zahodne, PhD

2. Acknowledgements • Funded in part by Grant R13AG030995-01A1 from the National Institute on Aging • The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

3. Collaborators Laura Zahodne Danurys Sanchez Yaakov Stern Richard Mayeux Nicole Schupf Maria Glymour Christopher Weiss Sze “Sam” Liu Adam Brickman Karen Siedlecki Supported by • NIA R01 AG16206 (PI: Manly) • NIA P01 AG07232 (PI: Mayeux)

4. WHICAP Inwood PI: Richard Mayeux Washington Heights Hamilton Heights • N > 6,500 older adults • Age 65 and older • Spanish or English speaking • Seen in home at 18 – 24 month intervals • Dementia dx based on neuropsychological test battery, medical & functional interview Percent of sample

5. Age-Specific Incidence of Alzheimer’s Disease Annual age-specific incidence Tang et al., 2001; Neurology 56: 49-56

6. Recruitment across 3 cohorts Consensus diagnosis of dementia at baseline • Inclusion/exclusion criteria • 1992: focus on prevalence in residents as is • 1999: focus on incidence in equal N ethnic groups, exclude for self-reported dementia diagnosis or serious memory complaints • 2009: + capacity to consent and willingness to give blood • Recruitment method • 1992/1999: Medicare lists • 2009: Relevate consumer data • Neighborhood • 65.5% reduction in crime 1993 to 2007

7. N and availability of measures Color Trails Neuropsych upon positive dementia screen Neuropsych as part of core visits PSES, Sleep Education and literacy questions Structural MRI CESD

8. Cognition Siedlecki 2008 2 = 1022.27 RMSEA = .04 CFI = .93

9. Childhood health variables • Adult height • Tibia Length

10. Childhood SES variables • Mother’s grade/credential • Father’s grade/credential • Mother’s occupation at age 16 • Father’s occupation at age 16 • Country and state of birth • Rural versus urban • Year of immigration • Number of siblings • Early death of parent

11. Education variables • Years of education • State of elementary & HS education • Historical quality variables • Private vs. public • Rural vs. urban setting • Racial/ethnic breakdown of schools • Size (one room school vs. multi-room)

12. Reading Level Del Ser et al., 1997

13. Adult SES variables • Years of education • Joint monthly income • Occupation during most of life • Own or rent home • (Neighborhood)

14. Adult health variables • Self-reported medical diagnoses • Hypertension • Diabetes • Heart disease • Stroke • Medication categories • Head injury history • Blood pressure • Height, weight, BMI • Lipids, HBA1C, Cpeptide, (glucose)

15. Adult health behavior variables • Smoking • Alcohol • Exercise questionnaire • Leisure activities questionnaire

16. Adult psychosocial variables • Marital status • Living status • DSM depression checklist • CES-D

17. Genetic variables • APOE genotype • GWAS