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South Carolina Commission on Higher Education October 6, 2011

South Carolina Commission on Higher Education October 6, 2011. Melanie Thomas, M.D., M.S. Associate Professor of Medicine Medical University of South Carolina Associate Director of Clinical Investigations Hollings Cancer Center Grace E. DeWolff Chair in Medical Oncology

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South Carolina Commission on Higher Education October 6, 2011

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  1. South Carolina Commission on Higher EducationOctober 6, 2011 • Melanie Thomas, M.D., M.S. • Associate Professor of Medicine Medical University of South Carolina • Associate Director of Clinical Investigations Hollings Cancer Center • Grace E. DeWolff Chair in Medical Oncology • Gastrointestinal Cancer Diagnostics Center of Economic Excellence

  2. Melanie B. Thomas, M.D.SmartState Endowed Chair –Gastrointestinal Cancer DiagnosticsEducation and Background

  3. National Cancer Institute Designation for Hollings Cancer Center • May 1, 2008, I signed offer letter to join MUSC-HCC as Associate Director of Clinical Investigations on August 1. • May 20, 2008 Core Grant Application submitted to NCI. • September 2008 NCI Site Visit, Charleston. • Responsible for Hollings Cancer Center Protocol Review and Monitoring System (PRMS), clinical trial accrual, quality. • December 2008 - Conditional approval received, citing 7 issues requiring response. • Resubmission December 2010 after extensive improvements. • Full approval of PRMS with laudatory comments January 2011.

  4. Gastrointestinal (GI) Cancers in SC • Two of every 5 South Carolinians will develop cancer in their lifetime. • SC ranks slightly higher than the US average for cancer incidence (new cases per 100,000) and mortality. • Cancers of the Gastrointestinal tract include: • Esophagus, stomach, small intestine, pancreas, liver, gallbladder, bile ducts, colorectal. • Cancer Registry data (1996-2001) GI cancers comprise 37% of all cancers in SC. • SC ranks 26th in the U.S. in colorectal cancer mortality. • Cancers of the liver and bile ducts are the fastest rising cancers in SC: • Annual increase 9.5% incidence, 2.2% mortality (similar to U.S.) • AA (men>women) with pancreatic, colorectal cancer, have worse outcome compared to Caucasians.

  5. GI Cancers at Hollings Cancer Center Gastrointestinal Cancers represent 18% of all tumor types seen at HCC in 2010

  6. Multidisciplinary Management of GI Cancers at MUSC • Patients benefit from comprehensive, multidisciplinary, integrated cancer care: • Digestive Disease Center nationally renowned, regional referral center. • Only liver transplantation program in SC. • 2 GI surgical oncologists trained at M.D. Anderson Cancer Center. • Interventional Radiology program offers therapeutic options not available elsewhere in SC. • Weekly Tumor Boards in GI cancers, Liver Tumors • Currently have 11 clinical trials active for GI cancer patients.

  7. SmartState Collaborations in GI Cancers: Charles D. Smith, PhD Cancer Drug Discovery Kenneth Tew, PhD Translational Cancer Therapeutics • Designed and activated a Phase I, First in Humans, first in class clinical trial of ABC 294640, novel drug developed by Dr. Smith and MUSC. • Have co-written numerous NIH, MUSC Grant Applications. Co-developed Biomarker Retreat to build a biomarker discovery program in clinical cancer research MUSC GI Cancers Research Program Studies effects of hypoxic and other injuries to liver cells, with liver transplant program. Developed pilot study of novel cancer vaccine for pancreatic cancer patients. Zihai Li, M.D. Cancer Stem Cell Biology John J. LeMasters, PhD Cancer Drug Discovery

  8. New Clinical Trials forGI Cancer Patients Hollings Cancer Center 2008-2011

  9. New Clinical Trials for GI Cancer Patients Hollings Cancer Center 2008-2011

  10. GI Cancer Research Future Initiatives

  11. South Carolina Commission on Higher EducationOctober 6, 2011 • Questions? • Gastrointestinal Cancer Diagnostics Center of Economic Excellence

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