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TRITOn Translational Informatics Research Platform

TRITOn Translational Informatics Research Platform. William Stephens The Ohio State University February 2011. What is TRITOn ?.

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TRITOn Translational Informatics Research Platform

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  1. TRITOnTranslationalInformaticsResearchPlatform William Stephens The Ohio State University February 2011

  2. What is TRITOn? The Translational Information Research Information Omnibus (TRITOn) is an integrative translational research information management platform. It is the product of an NCI funded re-engineering effort of the CSIM software used by the Chronic Lymphocytic Leukemia Research Consortium (CLL-CRC). CLL-CRC • Translational research targeting Chronic Lymphocytic Leukemia (CLL) • Established in 1999 • Cohort of over 5,000 patients • Comprehensive phenotypic and bio-molecular data sets, as well as bio-specimens • 8 participating sites

  3. Goals Goals of the project: • Modernize the technologies underlying the CRC’s clinical and translational research information management systems, including grid technologies and a modern web application framework. • Provide CRC participants with access to tools capable of enabling an increase in research productivity: • Data exchange • Bio-specimen management • Adverse event detection • Protocol-driven decision support • Integrative query and data aggregation • Provide community access to resulting technologies

  4. Platform Overview Clinical Trials Management Basic Science Data Capture Bio-specimen Management

  5. Application Architecture – 5/2012

  6. Grid Service Information • Grid Service Specifics (Directory, Protocol and Participant) • caGrid 1.3.0.2 • caCORE 4.2 • Writable API • Data Services with analytical operations • Local API – no caCORE web applications needed • caTissue • Custom caTissue data service using version 1.1.1 domain model • Uses standard grid security to authorize grid user access • Grid users can query using CSM configurations specific to their role. • caAERS • caAERS service to allow querying of adverse event codes • Support for electronic adverse event reporting

  7. Web Application Information • Java-based User Interface • Uses Google Web Toolkit version 2.1 (latest release) • Uses MVP (model view presentation) architecture • Purposely uses a clean Google-like interface • Integrates with caGrid • Dorian Service • user registration and authentication • Directory Service • Institution, Site, User and Participant information • Protocol Service • Creation and management of clinical protocols • Participant Service • Management of Participant enrollment and CRF data collection • caTissue Service • Tissue Sample management

  8. UI Appearance

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