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Urinary tract infections in children What investigations?. Yves Heloury FRACS, Pediatric Urology. UTI- General considerations. 3 determinants in pediatrics Age Sex F ever UTI: 2 different situations Infants and young children with febrile UTI Toilet trained girls with afebrile UTI.
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Urinary tract infections in childrenWhat investigations? Yves Heloury FRACS, Pediatric Urology
UTI- General considerations • 3 determinants in pediatrics • Age • Sex • Fever • UTI: 2 different situations • Infants and young children with febrile UTI • Toilet trained girls with afebrile UTI 2
UTI- General considerations • UTI: 3 steps • Diagnosis of UTI • Pyuria > 10 WBCs per μL • Bacteriuria > 105 CFU per ml • Treatment • Etiology and 4
UTI- General considerations • Precise diagnosis • Treatment of children WITH UTI • Limited investigations • Focused more on function than on anatomy • Kidneys +++ • Bladder 5
UTI- Children under 2 years • Guidelines AAP: Pediatrics 2011 http://pediatrics.aappublications.org/content/early/2011/08/24/peds.2011-1330 • Infants and young children (2 to 24 months) • Fever > 38 • In a child with fever and no other clinical source of infection, the risk of UTI is 5% 6
UTI- Children under 2 years (Guidelines AAP) Infant with fever UTI 5% Poor clinical tolerance Good clinical tolerance + SPA or catheterization Bag or Dipstick + - Antibiotherapy No UTI 7
UTI- Guidelines AAP • Treatment • Oral antibiotherapy, except toxic child, digestive trouble • Duration: 7 to 14 days • After, no antibioprophylaxis if ultrasound normal • UTI in boys: discuss circumcision 9
UTI- Guidelines AAP Investigations • Clinical examination • Abdomen (kidneys, bladder) • Genitalia • Sacrum 10
UTI- Guidelines AAP Renal US • systematic except if high quality prenatal US at the third trimester • Why: detect dilatation ureters or pelvis; size of kidneys; renal abcess • When: not as emergency, except no clinical improvement after 2 days of ATB US abnormal in 15% but action in only 2% 11
UTI- Guidelines AAP • First pyelonephritis • No other investigation, except dilatation of ureter and/or pelvis • Recurrent UTI (10%) • DMSA nuclear medicine • Scarring • 4 to 6 months after UTI • MCUG (VUR, Bladder, urethra) 12
UTI in young children- Take home messages • Diagnosis is difficult • First UTI: ultrasound • Recurrences: DMSA and MCUG • Early treatment decreases scarring • Renal alterations are for a large part related to prenatal dysplasia 13
UTI in older children • General considerations • Girls > 5 years • Cystitis with voiding disorders and/or constipation • Can be associated with episodes of pyelonephritis • Urinalysis only if pain • No urinalysis nor antibiotics for abnormal • color • odor 14
UTI in older children • Clinical investigation • Previous history: toilet training, sexual abuse • Bladder function: fluid intake, dryness, diary • Bowell function: diet, soiling, consistency of poos • Abdomen, genitalia, sacrum • Neurological evaluation: Feet (tethered cord) 15
UTI in older children • Paraclinic investigations • 1 or 2 cystitis: nothing • Recurrent cystitis • Uroflowmetry • Renal and bladder US • kidneys • pre and postvoiding volume • constipation • If associated pyelonephritis: DMSA nuclear medicine 16
UTI in older children • Management • Bowell management: diet, fluid, movicol • Bladder management: urotherapy to improve bladder emptying (relaxation of pelvic floor, position on the toilets, double voiding) • Cranberry juice? • Medications • Antibiotics for symptomatic UTI • No long term antibioprophylaxis • Alpha blockers (bladder emptying) 18
UTI in toilet trained children- Take home messages • Cystitis mainly related to constipation and poor bladder emptying • Investigation and management: bowel and bladder • Conservative management as long as the upper urinary tract is normal • Management of familial anxiety 19