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Trigeminal System. Useful animations:. https://www1.columbia.edu/sec/itc/hs/medical/neruoanatomy/neuroanat/. Somatic sensory: A007. Sensory cranial: F003. Sensory cranial: F004. Somatic sensory: AN01. Somatic sensory: A006. Readings: Principles of NS
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Useful animations: https://www1.columbia.edu/sec/itc/hs/medical/neruoanatomy/neuroanat/ Somatic sensory: A007 Sensory cranial: F003 Sensory cranial: F004 Somatic sensory: AN01 Somatic sensory: A006 Readings: Principles of NS General somatic sensory organization: 447-449 Brain stem/cranial nerve review: 873-880 Sensory nuclei : 880-882, Fig 44-6
Nociceptors, thermoreceptors, & itch receptors are bare nerve endings Mechanoreceptors are encapsulated Bare nerve ending Merkel’s receptor Meissner’s corpuscle Pacinian corpuscle
Dorsal horn Anterolateral system: spino-thal spino-retic spino-mesen
Components of the trigeminal system • Spinal nucleus • Caudal nucleus Pain/temp/itch • Interpolar nucleus Pain/reflexes, etc, ??? • Oral nucleus Reflexes, etc, ??? • Main sensory nucleus Mechanosensation • Mesencephalic nucleus Jaw proprioception • Motor nucleus Jaw muscles
Mesencephalic Trigeminal motor Main sensory Spinal trigeminal nuc: oral interpolar caudal
Organization of the spinal trigeminal nucleus: caudal nucleus
Ophthalmic division Maxillary division Mandibular division 7, 9, & 10 3 C2 2 1 C2 Interpolar nucleus 3 Caudal nucleus 2 1 C2 Upper spinal cord
Input: Small-diameter fibers Marginal zone Substantia gelatinosa Spinal trigeminal tract Caudal nucleus Output: Marginal zone-->Thalamus, midbrain Substantia gelatinosa-->interneurons
Spinal trigeminal tract Caudal nucleus Anterolateral system
Trigeminal lemniscus Medial lemniscus Main sensory Anterolateral/ trigeminothal Trigeminal motor Medial/trigeminal lemniscus
Mesencephalic Nucleus &tract
Mesencephalic Nucleus &tract
Somatic Sensory Thalamus Medial dorsal Ventral posterior medial-VPM (trigem) Ventral posterior lateral-VPL (spinal) Touch Pain Ventral posterior (VMpo)
Anterolateral and Trigeminal Systems Ventral posterior-->Postcentral gyrus •localization
Anterolateral System Ventral medialpost-->Insular •behavioral & •autonomic responses •“Limbic” Amygdala
Anterolateral and Trigeminal Systems Medial dorsal-->Cingulate gyrus •emotional (-valence…) •“Limbic”
- Pain suppression path Limbic cortex Periaqueductalgray matter Raphe nuclei(5-HT) Caudal nucleus
Trigeminal System • Separate components for pain and touch • Brain stem nuclei: • Caudal nucleus (pain) • Interpolar nucleus (caudal part for pain-mouth) • Oral nucleus (???) • Main sensory nucleus • 3 Separate thalamic pain nuclei & 1 for touch: • Pain (VPM, VMpo, MD) • Touch (VPM) • 3 Separate cortical representations: • Postcentral gyrus (localization) • Insular (important for pain) • Cingulate (emotions, esp. for pain) • Pain suppression system • PAG-->Raphe nuclei (5-HT)-->Caudal nucleus