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Animals in Research Donald B. Casebolt, DVM, MPVM, DACLAM

Animals in Research Donald B. Casebolt, DVM, MPVM, DACLAM. Objectives. Responsibilities of the institution Responsibilities of the principal investigator and his/her staff members.

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Animals in Research Donald B. Casebolt, DVM, MPVM, DACLAM

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  1. Animals in Research Donald B. Casebolt, DVM, MPVM, DACLAM

  2. Objectives Responsibilities of the institution Responsibilities of the principal investigator and his/her staff members

  3. “The development of knowledge necessary for the improvement of the health and well-being of humans as well as other animals requires in vivo experimentation with a wide variety of animal species.” (United States Office of Science and Technology Policy, 1985)

  4. Federal Laws Animal Welfare Act US Department of Agriculture Health Research Extension Act National Institutes of Health Office of Laboratory Animal Welfare

  5. Similarities of Two Laws Both require an Institutional Official Both require an Institutional Animal Care and Use Committee Both require a program of veterinary care Both require adequate training of personnel “Enforced Self-Regulation”

  6. AAALAC Accreditation

  7. IACUC Membership Scientist Veterinarian with training and/or experience in laboratory animal medicine Nonscientist At least one member not affiliated with the institution (public member)

  8. IACUC Responsibilities Review the programs of animal care and use Inspect animal facilities and animal housing areas Approve, require modifications prior to approval, or withhold approval of animal use protocols Approve any changes to an animal use protocol The IACUC is authorized to suspend a protocol

  9. Attending Veterinarian Responsibilities Ensure adequate and proper animal care and use and veterinary care Work in concert with the IACUC and Principal Investigators Exercise professional judgment to facilitate the science in the context of animal welfare Implement policies using scientifically sound, performance-based standards Establish effective training programs

  10. Principal Investigator Responsibilities Preparation and submission of Animal Use Protocols and modifications to protocols Justification of species and numbers of animals Training of personnel in appropriate methods Occupational health and safety of personnel Minimization or avoidance of animal pain and distress Development of experimental endpoints Surgery and post-surgical care Animal euthanasia methods

  11. Training • Species-specific • Protocol-specific (covers laboratory procedures)

  12. Training • Web Based • Lecture and hands on

  13. Questions?

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