Animals in Research Donald B. Casebolt Director, Department of Animal Resources

1. Animals in Research Donald B. Casebolt Director, Department of Animal Resources

2. Objectives Responsibilities of the institution Responsibilities of the principal investigator

3. “The development of knowledge necessary for the improvement of the health and well-being of humans as well as other animals requires in vivo experimentation with a wide variety of animal species.” (United States Office of Science and Technology Policy, 1985)

4. Federal Laws Animal Welfare Act US Department of Agriculture Health Research Extension Act National Institutes of Health Office of Laboratory Animal Welfare

5. Similarities of Two Laws Institutional Official Institutional Animal Care and Use Committee Program of veterinary care Training of personnel “Enforced Self-Regulation”

6. AAALAC Accreditation

7. IACUC Membership Scientist Veterinarian with training and/or experience in laboratory animal medicine Nonscientist At least one member not affiliated with the institution (public member)

8. IACUC Responsibilities Review the programs of animal care and use Inspect animal facilities and procedure areas Approve, require modifications prior to approval, or withhold approval of animal use protocols Approve any changes to animal use protocols The IACUC is authorized to suspend a protocol

9. Principal Investigator Responsibilities Preparation and submission of Animal Use Protocols Modifications to protocols Justification of animal species and numbers Training of personnel in appropriate methods Occupational health and safety of personnel Avoidance of animal pain and distress Development of humane endpoints Animal euthanasia methods

10. iStar for IACUC

11. iStar for IACUC

12. iStar for IACUC

13. iStar for IACUC

14. Training • Species-specific • Protocol-specific • Web based and hands-on

15. Questions?