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Schizophrenia: The d[iy]sconnection hypothesis DH

Overview. The dysconnection hypothesisFunctional connectivitySynaptic PlasticityEvidence for synaptic plasticity in schizophreniaDH and Guidel Summer schoolReinforcement learningCorollary dischargePrediction codingExplanatory powerHeterogeneity of schizophreniaPeak of onsetGene-environmen

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Schizophrenia: The d[iy]sconnection hypothesis DH

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    1. Schizophrenia: The d[i|y]sconnection hypothesis (DH) Summer school Guidel - 2011 Group: “Neurocomputational models of maladaptive behavior and psychiatric disease” Presenter: Carina Pika 09/14/2011

    2. Overview The dysconnection hypothesis Functional connectivity Synaptic Plasticity Evidence for synaptic plasticity in schizophrenia DH and Guidel Summer school Reinforcement learning Corollary discharge Prediction coding Explanatory power Heterogeneity of schizophrenia Peak of onset Gene-environment interaction Drug effects

    3. Functional connectivity in the DH Karl J. Friston, 1997 “dis”connection vs. “dys”connection Schizophrenia‘s pathophysiology as a failure of proper functional integration Functional integration Integration of functionally specialized systems (e.g. cortical areas) ? required for adaptive sensorimotor integration and cognition Not anatomical, but functional No regionally specific pathophysiology, but dysfunctional integration Key concept: synaptic plasticity The dysconnection hypothesis

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