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Transcription & Translation

Transcription & Translation. Figure 10.7. DNA molecule. Gene 1. Gene 2. Gene 3. DNA. C. C. A. A. A. C. G. G. A. A. A. A. Transcription. RNA. G. G. C. C. G. U. U. U. U. U. U. U. Translation. Codon. Polypeptide. Amino acid. Figure 10.7_1. DNA. A. A. A. C.

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Transcription & Translation

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  1. Transcription & Translation

  2. Figure 10.7 DNAmolecule Gene 1 Gene 2 Gene 3 DNA C C A A A C G G A A A A Transcription RNA G G C C G U U U U U U U Translation Codon Polypeptide Aminoacid

  3. Figure 10.7_1 DNA A A A C G G C C A A A A Transcription U U U G G C C G U U U U RNA Codon Translation Polypeptide Aminoacid

  4. http://mjlightfoot.edublogs.org/files/2011/06/07-DNA-vs-RNA-2-29jz9yv.GIFhttp://mjlightfoot.edublogs.org/files/2011/06/07-DNA-vs-RNA-2-29jz9yv.GIF

  5. Figure 10.8B_s3 Strand to be transcribed T T T C A T C A A A C A DNA A A T T A G T A G T G T Transcription RNA A A A U U A G G U G U U Startcodon Stopcodon Translation Met Lys Phe Polypeptide

  6. Figure 10.11B Enzyme tRNA ATP

  7. Figure 10.12B tRNA binding sites Large subunit Psite Asite Small subunit mRNA binding site

  8. Figure 10.13B Met Met Largeribosomalsubunit InitiatortRNA Asite Psite mRNA U C U C A A A U G A U G Start codon Smallribosomalsubunit 1 2

  9. http://www.youtube.com/watch?v=5bLEDd-PSTQ&feature=related http://www.youtube.com/watch?v=4PKjF7OumYo&feature=related (go to 4:36)

  10. Figure 10.15 Transcription DNA Transcription 1 mRNA RNApolymerase CYTOPLASM Translation Amino acid Amino acid 2 attachment Enzyme tRNA ATP Anticodon InitiatortRNA Largeribosomalsubunit Initiation of 3 polypeptide synthesis Start Codon Smallribosomalsubunit mRNA New peptidebond forming Growingpolypeptide Elongation 4 Codons mRNA Polypeptide Termination 5 Stop codon

  11. Figure 10.16A Normal hemoglobin DNA Mutant hemoglobin DNA C T C T A T mRNA mRNA U G A G A A Normal hemoglobin Sickle-cell hemoglobin Val Glu

  12. Figure 10.16B Normalgene A U G A A G U U U G G G C C A mRNAProtein Gly Ala Met Lys Phe A A U G A A G C C A G U U U G Nucleotidesubstitution Lys Ala Phe Met Ser U Deleted U G G U U G G C A U G A A C A Nucleotidedeletion Ala Leu Lys Met His Inserted U G G G G U U G C A U G A A Nucleotideinsertion C Ala Leu Lys Met His

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