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Fungal Infections Parasitic infections

Pathology. Fungal Infections Parasitic infections. Fungal Infections. Candida albicans. Candidiasis. C. albicans Most common human infection Adapts rapidly Phenotypic switching Adhesion Virulence Yeast Mannose Hypha C om p lement receptor and Fc γ receptor. Candidiasis.

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Fungal Infections Parasitic infections

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  1. Pathology Fungal InfectionsParasitic infections

  2. Fungal Infections

  3. Candida albicans

  4. Candidiasis • C. albicans • Most common human infection • Adapts rapidly • Phenotypic switching • Adhesion • Virulence • Yeast • Mannose • Hypha • Complement receptor and Fcγ receptor

  5. Candidiasis • Candida vaginitis • Cutaneouscandidiasis • Invasive candidiasis

  6. Oral Thrush

  7. Cryptococcosis • Cryptococcus neoformans • Opportunistic infection • Virulence factors • Polysaccharide capsule • Glucuronoxylomannin • Anti-phagocytic • Phenotypic switching • Melanin production • antioxidant properties • Enzymes • serine proteinase • invasiveness

  8. Aspergillusfumigatus

  9. Aspergillosis • Allergic BronchopulmonaryAspergillosis • Immunocompromised • Sinusitis • Pneumonia • Invasive disease • Neutropenia and Corticosteroid use • Aflatoxin B1

  10. Colonizing Aspergillosis (Aspergilloma)

  11. Invasive Aspergillosis

  12. Zygomycosis • Opportunistic • Mucormycosis and Phycomycosis • Mucor, Rhizopus, Absidia, and Cunninghamella

  13. Rhinocerebralmucormycosis

  14. Cutaneousmucormycosis

  15. Pulmonary zygomycosis

  16. Parasitic Infections

  17. Malaria • Plasmodium • P. vivax • P. falciparum • P. ovale • P. malariae • P. knowlesi

  18. Malaria • 500 million infected and kills more than 1 million people each year • kills one child every 30 seconds • kills 3000 children per day under five years of age

  19. Anopheles flavirostris

  20. Malaria • P. falciparum • P. falciparum erythrocyte membrane protein • PfEMP1 • Knobs on RBC and attached to endothelial cells • High cytokine production • Further enchance RBC sequestration

  21. Plasmodium falciparum • HbS • Sickle cell anemia • HbC • Duffy antigen

  22. Plasmodium falciparum • Malignant cerebral malaria • Malarial of DÜrckgranuloma

  23. Babesosis • Babesiamicroti • Splenectomized patients

  24. Blood and Tissue Flagellates

  25. Leishmaniasis • Promastigote • Macrophage infection • Lipophosphoglycan • Surface glycoconjugates • Membrane attack complex formation avoided • Inhibits lysosomal enzymes • Gp63 • Fibronectin • Amastigote • proton-transporting ATPase

  26. Leishmaniasis

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