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Fungal Infections

Fungal Infections. Meningitis : • Cryptococcus (#1 fungal cause) • Coccidioides (SW USA) • Histoplasmosis (small %) Brain abscesses: • Aspergillosis • Zygomycosis (esp. Rhizopus). Primary skin lesions: • Dermatocytes • Candida Secondary skin lesions: • Blastomycosis. Pulmonary :

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Fungal Infections

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  1. Fungal Infections

  2. Meningitis: • • Cryptococcus (#1 fungal cause) • • Coccidioides (SW USA) • • Histoplasmosis (small %) • Brain abscesses: • • Aspergillosis • • Zygomycosis (esp. Rhizopus)

  3. Primary skin lesions: • • Dermatocytes • • Candida • Secondary skin lesions: • • Blastomycosis

  4. Pulmonary: • • Histoplasmosis • • Blastomycosis • • Cryptococcus • • Pneumocystis • • Aspergillosis • • Zygomycosis

  5. Liver: • • Histoplasmosis • • Candida • Kidney: • • Candida • Sexually-Transmitted: • • Candida

  6. RES(reticuloendothelial system – lymph nodes, spleen; monocytes, macrophages, de ndritics) • • Histoplasmosis • GI: • • Candida • • Histoplasmosis • • Zygomycosis • • Aspergillosis

  7. Decreased Neutrophils – necrosis & deep abscesses: • • Aspergillosis • • Zygomycosis • • Invasive Candida

  8. Host-Dependent T-Cell Involvement: • • Coccidioides • • Histoplasmosis • • Blastomycosis • • Cryptococcus • Normal T-cells  caseating granuloma; few organisms Moderate T-cells  loose granuloma; moderate organisms Immunocompromised/HIV  no granuloma, many organisms

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