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USF – Bioinformatics Master Project

USF – Bioinformatics Master Project. Outline Buck Institute The Mooney Lab Project Description . Buck Institute for Research on Aging. History. The San Francisco Foundation established . (at the time estimated at $11 - $12 million ). 1975. 1986.

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USF – Bioinformatics Master Project

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  1. USF – Bioinformatics Master Project • Outline • Buck Institute • The Mooney Lab • Project Description

  2. Buck Institute for Research on Aging History • The San Francisco Foundation established. • (at the time estimated at $11 - $12 million) 1975 1986 • 1986 – The “Buck Institute on Aging” was incorporated. 1987 • 1987 – the Marin Superior Court selected the Institute to receive 15% of the net income from Beryl Buck’s estate 1989 • 1989 – the Buck purchased a 488-acre parcel of undeveloped land on Mt. Burdell in Novato 1996 • 1996 – construction began 1999 • 1999 – The buck opened • 2010 – the value of the Buck Trust had grown to over $700 million, generating an annual income for the Institute of approximately $6 million per year. 2010

  3. Buck Institute for Research on Aging The Future for the Buck New construction for stem-cell lab building - $41 million project

  4. Buck Institute for Research on Aging The Buck Today • Mission – To increase the healthy years of life by investigating how • normal aging contributes to the development of diseases. • Employees – 200 • Faculty – 18 labs

  5. Buck Institute for Research on Aging Main research focus: • Parkinson disease • Alzheimer • cancer • stroke • nutrition • stress • genetics • stem cells • bioinformatics

  6. The Mooney Lab • Responsibilities • Core – support other labs in the institute to: • handle, store, and retrieve data • analyze biological data • use tools to generate biological hypotheses • Independent research – • identify and classify diseases causing mutations • analyze protein structure to estimate structure similarities, predict catalytic and protein-protein interaction sites. • using ontologies to classify gene function

  7. Life Science Web Services Plug-ins Plugin- a container for a group of related resources (software components), embedded in a larger software application to extend its functionality. LSW Plugin LSW Plugin Pymol Chimera Lab’s Web Tools

  8. Life Science Web Services Plug-ins Integration • Lab’s Web Tools: • S-Blest • CRP • MutDB • PPI LSW Services: • Chimera, Pymol: • Analyze molecular structure • Provide: images, animations, • interactive Visualization distutils API SOAP setuptools WSDL Easy Install p53 Cancer Mutations Egg files Packages MD5 services

  9. USF – Bioinformatics Master Project Contact info: tronnenoron@buckinstitute.org

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