1 / 4

What adjuvant treatment is required?

What adjuvant treatment is required? . Stage Iva combined modality Surgery + radiation Chemotx + radiation for advanced larynx or hypopharynx lesions. Radiotherapy. For Stage 3 & 4 Radiation pre or postop Indicators for postoperative adjuvant radiation therapy:

lynley
Download Presentation

What adjuvant treatment is required?

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. What adjuvant treatment is required? • Stage Iva • combined modality • Surgery + radiation • Chemotx+ radiation for advanced larynx or hypopharynxlesions

  2. Radiotherapy For Stage 3 & 4 • Radiation pre or postop • Indicators for postoperative adjuvant radiation therapy: • Presence of negative prognostic factors such as extracapsular spread of tumor, perineural invasion, vascular invasion, fixation to surrounding structures, and multiple positive nodes • Preoperative radiation or chemoradiation therapy • Given when patients have advanced neck disease that involves the carotid artery or the deep neck musculature, in the hope that the tumor reduces in size and becomes resectable. • 50 to 70 Gy over 5 to 7 weeks • Adverse Effect: • Acute: mucositis, skin erythema • Late: fibrosis, xerostomia, altered taste, risk of osteoradionecrosis

  3. Chemotherapy • No survival advantage for HNSCC compared to surgery and/ or radiation • Role of chemotherapy: • as a radiation sensitizer • Palliation (symptom control) of recurrent or unresectable disease, combined with radiation • Cisplatin, carboplatin, 5-FU

  4. References: • Townsend et.al, “Sabiston Textbook of Surgery”, 18th ed.

More Related