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G-protiens: Activated when first messenger binds receptor can move along PM an activate an effector protein on PM

receptor. effector. β. α. γ. G-protiens: Activated when first messenger binds receptor can move along PM an activate an effector protein on PM. receptor. enzyme. β. Second messenger. α. Effect/cell response. γ. G-protiens with second messengers

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G-protiens: Activated when first messenger binds receptor can move along PM an activate an effector protein on PM

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  1. receptor effector β α γ G-protiens: Activated when first messenger binds receptor can move along PM an activate an effector protein on PM

  2. receptor enzyme β Second messenger α Effect/cell response γ G-protiens with second messengers First messenger binds receptor activates the g-proteins which binds an enzyme which produces a second messenger

  3. receptor effector Pi GDP β • Effector: • Opens/closes ion channel • Activates an enzyme α GTP GDP γ G-Linked Proteins: general scheme of how g-proteins are activated. Note in some cases the alpha subunit stays stationary and the beta-gamma unit moves the the effector.

  4. On the next slide click a button to begin the animation, then the animation should run automatically

  5. Na+ ion channel + + + + + + + + receptor Pi GDP β - - - - - - - - - α GDP GTP • Opens ion channel • Na+ (or Ca+) flows in • inside of cell become less negative  depolarizes  EPSP + + + γ MUSCARINIC RECEPTORS—EPSP through closing of K+ channel--FINISH

  6. Na+ ion channel + + + + + + + + receptor Pi GDP β - - - - - - - - - α GDP GTP • Opens ion channel • Na+ (or Ca+) flows in • inside of cell become less negative  depolarizes  EPSP + + + γ MUSCARINIC RECEPTORS—EPSP through opening of ion channel Note that the ion channels can also be closed in some cases.

  7. On the next slide click a button to begin the animation, then the animation should run automatically

  8. KA • Effector: • Activates cAMP adenylate cyclase receptor cAMP Pi GDP β + α GDP GTP + Pi + ATP γ Adrenergic β1 & β2 receptors--EPSP

  9. KA • Effector: • Activates cAMP adenylate cyclase receptor cAMP Pi GDP β + α GDP GTP + Pi + ATP γ Adrenergic β1 & β2 receptors--EPSP

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