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Prostate Cancer – a model of Epigenetic Catastrophe?

Prostate Cancer – a model of Epigenetic Catastrophe?. A Perry et al,, End. Rel. Cancer 2006. PBOX-15 induces apoptosis in primary B-CLL cells. control. Propidim Iodide. 1 m M PBOX-15. Annexin V - FITC. n=34 p < 0.0001 Paired t test, t = 13.69, 33df.

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Prostate Cancer – a model of Epigenetic Catastrophe?

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  1. ProstateCancer – a model of Epigenetic Catastrophe? A Perry et al,, End. Rel. Cancer 2006

  2. PBOX-15 induces apoptosis in primary B-CLL cells control Propidim Iodide 1mM PBOX-15 Annexin V - FITC n=34 p < 0.0001 Paired t test, t = 13.69, 33df

  3. Hypoxic induction of CD gene expression Prodrug 5-Fluorocytosine (5-FC) HIF1- HIF-1 HIF1- HRE Promoter CD Anti-cancer drug 5-Fluorouracil (5-FU) • Localised chemotherapy • Sensitisation of hypoxic cells • Improvement of RT outcome? Radiation

  4. Legends to Figures Figure 1: Identifying a haplotype linked to risk of developing Myeloma by SNP pathway analysis Figure 2: Evolutionary Conservation of the SNP in XRCC5 linked to Myeloma Figure 3: Prostate Cancer, a model of Epigenetic catastrophe? The figure indicates some of the potential target of epigenetic modification in prostate cancer Figure 4: PBOX compounds as anti-leukaemia agents – demonstration of efficacy in primary CLL cells Figure 5: Promoting targeted killing of tumour cells through a suicide gene therapy approach

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