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Statin Drugs

Individual level risk factors for cardiovascular disease. High Blood Pressure High Blood CholesterolTobacco UsePhysical inactivityPoor nutritionObesityDiabetes. High Cholesterol Profile. Percent of Americans ages 20-74 with high serum cholesterol: 19% Mean serum cholesterol level, mg/dl: 203

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Statin Drugs

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    1. Statin Drugs Cholesterol lowering drugs

    2. Individual level risk factors for cardiovascular disease High Blood Pressure High Blood Cholesterol Tobacco Use Physical inactivity Poor nutrition Obesity Diabetes

    3. High Cholesterol Profile Percent of Americans ages 20-74 with high serum cholesterol: 19% Mean serum cholesterol level, mg/dl: 203 High serum cholesterol is most prevalent among white, non-Hispanic females High serum cholesterol is least prevalent among Black males

    4. Cholesterol Vital constituent of all cells since it is part of the cell membrane Also used in the synthesis of sex hormones Also used to make bile salts Synthesized in liver from saturated fatty acids and also absorbed by small intestines from animal foods If diet low in cholesterol liver responds and makes more

    5. Cholesterol However, if the diet is rich in cholesterol then synthesis within the body virtually stops Cholesterol production is controlled by a feedback mechanism in which cholesterol inhibits the enzyme b-hydroxy-b-methylglutaryl-CoA reductase (HMG Co-A reductase). By inhibiting this enzyme, the conversion of HMG-CoA to mevalonic acid is stopped

    6. Cholesterol synthesis

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