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I Zapolsky, E Kyzar , S Gaikwad , A Roth, J Green,

I Zapolsky, E Kyzar , S Gaikwad , A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA) . ZEBRAFISH NEUROPHENOME PROJECT . The ZNP was started by the ZNRC , and is dedicated toward producing a ZND Let’s start by defining these acronyms.

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I Zapolsky, E Kyzar , S Gaikwad , A Roth, J Green,

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  1. I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

  2. ZEBRAFISH NEUROPHENOME PROJECT • The ZNP was started by the ZNRC, and is dedicated toward producing a ZND • Let’s start by defining these acronyms

  3. The ZNRCZebrafish Neuroscience Research Consortium Allan Kalueff - USA Georgianna Gould - USA Oliver Braubach - Canada Anderson Manoel Herculano - Brazil David Echevarria - USA Joe Schroeder - USA Jason Warnick - USA Dominic Wright - SwedenCarla Denise Bonan - BrazilMônica Ryff Moreira Roca Vianna - BrazilZofia Zukowska - USA

  4. The main goal of ZNRC is to promote zebrafish neuroscience research. • Created in February 2010, ZNRC offers excellent networking opportunities and peer support for active zebrafish labs.

  5. ZNDZebrafish Neurophenome Database • Goals: • Pioneering • Accessible • Easy to use • Useful

  6. Emerging Model Organism • The Zebrafish is an emerging model animal for vertebrate development and neurological function • Offers a good compliment to other animal models • Advantages • Easy to take care of • Inexpensive • Easy to test • Quantifiable behavioral endpoints

  7. Inspiration • Mice Mouse Genome Informatics (G+P) Mouse Phenome Database (P) • Rats Rat Genome Database (G) National BioResource Project (P) • Zebrafish ZFIN (Genome) NCBI (Genome) • The point? • A Phenome database for the Zebrafish does not yet exist, but inevitably will sometime soon

  8. PubMed search“zebrafish” 1900-1985 - 61 papers 1985-1990 - 114 papers 1990-1995 - 487 papers 1995-2000 - 1981 papers 2000-2005 - 4946 papers 2005-2010 - 7538 papers Between 2005 and 2010 the total number of zebrafish-related papers ever written doubled.

  9. ZNDZebrafish Neurophenome Database • Goals: • Pioneering(so far) • Accessible • Easy to use • Useful

  10. www.kaluefflab.com/znpindex-or-www.tulane.edu/~znpindex/searchwww.kaluefflab.com/znpindex-or-www.tulane.edu/~znpindex/search

  11. ZNDZebrafish Neurophenome Database • Goals: • Pioneering (so far) • Accessible (the internet) • Easy to use • Useful

  12. What we see, Not easy

  13. What you’ll see

  14. What you’ll see

  15. What you’ll see

  16. Everything you need to know… Hopefully

  17. If not.. • Submit your data! • More on this later

  18. How it’s organized Parent/Child Format Experiment 1 Interval 1.2 Interval 1.3 Interval 1.1 Treatment 1.1.1 Treatment 1.1.2

  19. Caffeine L/D Box Experiment Acute withdrawal Chronic 15 min Interval 100 mg/kg I.P. 250 mg/kg I.P. Treatment

  20. that’s what you’re seeing here Experiment Interval Treatment Test Results

  21. ZNDZebrafish Neurophenome Database • Goals: • Pioneering(so far) • Accessible(the internet) • Easy to use(we hope so) • Useful

  22. Only With Your Help • Submit your data! (2 methods) • Direct info submission with the submission template (next slide) • Send us a paper (please use step #1)

  23. Submission Template

  24. If you send us a paper…

  25. We fill out the template

  26. ZNDZebrafish Neurophenome Database • Goals: • Pioneering(so far) • Accessible(the internet) • Easy to use(we hope so) • Useful(with your help)

  27. Special Thanks • Budd Hirons - who has been essential to the actualization of this idea. • ILC (Innovative Learning Center) & Tulane University Technology Services • Also, Tulane has been kind enough to supply us with the server space that is required to host such a database.

  28. In Conclusion • The Zebrafish is an emerging animal model for vertebrate development and neurological function • We hope to work closely with other zebrafish-based databases to help provide a better, more comprehensive user experience • Check in regularly at: • http://www.tulane.edu/~znpindex/search • Or just search ZNP or Zebrafish Phenome • You can help by submitting your data.

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