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Uridine 10% hand-foot-ointment and adhesive-paste

Learn about Uridine, an effective treatment for hand-foot syndrome and mucositis caused by 5-FU and its derivatives. Discover the development process and formula, as well as the ongoing ESOP study evaluating its efficacy.

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Uridine 10% hand-foot-ointment and adhesive-paste

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  1. Uridine 10% hand-foot-ointment and adhesive-paste For the treatment of the hand-foot syndrome (PPE) and mucositis induced by of 5-FU and its oral derivates (Capecitabine, UFT) Jürgen Barth, Essen

  2. The (short) story of how it came into being • Side effects of 5-FU (& derivates): • PPE • Mucositis • Pharmacological considerations about an „antidot“ in the 90ies • Various substances seemed to be a possibility • Thymine • Thymidine • Uracil • Uridine • 2‘-Deoxyuridine Jürgen Barth, Essen

  3. The (short) story of how it came into being • Decision: Uridine • Development of a formula in the Dept.of Pharmacy, Essen • “Clinical experience“ after a short time: IT WORKS • Since then: an “in-house-speciality” • Useful after extravasation or skin contamination • Uridin-Hand-Fußsalbe und Uridin-Haftpaste als effektive Antidota nach akzidenteller Hautkontamination mit 5-Fluorouracil – ein Fallbericht Krankenhauspharmazie 2000; 21: 625-628 • Evidence based data concerning efficacy (by systematical inquiry): NONE Jürgen Barth, Essen

  4. Uridine 10% hand- & foot ointment Uridin 10 g Propylene glycol q.s. Basiscreme DAC ad 100 g Uridine 10% adhesive-paste Uridin 1 g Subliquid paraffin 6,65 g Carbopol 934 2,35 g Spearmint oil 1 gtt. The formulae • Uridine is added to a hydrophobic adhesive-paste composed of subliquid paraffin and Carbopole 974P, a type of polyacrylic acid. • The paste is flavoured with spearmint oil. • Uridine is mixed with a small amount of propylene glycol. • This dispersion is then added to DAC basic cream. • DAC basic cream is monographed in the Deutscher Arzneimittel Codex (German drug codex), representing a collection of drug monographs besides the European and German Pharmacopoeia. • DAC basic cream is an amphiphile nonionic cream. Jürgen Barth, Essen

  5. Aim of an ESOP study • Systematical data collection to evaluate the efficacy of the ointment and –if possible- the adhesive (mucous membrane) paste • How? ESOP will make the formulae (instructions how to prepare a drug) available to any interested pharmacist who feels able to prepare these medication and offer it to physicians who treat patients with 5-FU, Capecitabine or UFT • Data will be collected by the individual pharmacist • Summary and evaluation by ESOP Jürgen Barth, Essen

  6. ESOP study Evaluation sheet (and this presentation) will be downloadable @ the ESOP homepage: http://www.esop.li/ Jürgen Barth, Essen

  7. ESOP study Evaluation sheet http://www.esop.li/ Jürgen Barth, Essen

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