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Synthesis and Characterization of Amphiphilic Dendron Coils – Potential Nanomicelle Precursors. Jeromy T. Bentley University of Illinois at Chicago RET Fellow Department of Biopharmaceutical Sciences RET Advisor : Dr. Seungpyo Hong RET Mentor : Ryan Pearson July 14 , 2011.
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Synthesis and Characterization of Amphiphilic Dendron Coils – Potential Nanomicelle Precursors Jeromy T. Bentley University of Illinois at Chicago RET Fellow Department of Biopharmaceutical Sciences RET Advisor: Dr. Seungpyo Hong RET Mentor: Ryan Pearson July 14, 2011
Summer Plan • Synthesize functionalized lipophilic polymer “coil” • Conjugate hydrophilic PEGylateddendron to lipophilic polymer coil to create amphiphilicdendron coil and induce self-assembled structure formation • Characterize synthesized amphiphilicdendron coils by 1H NMR • Characterize self-assembled micelles by TEMand DLS • Measure critical micelle concentration, zeta potential, and cellular uptake
Background - Dendron Coils • Dendron Coils – linear polymer that is dendronized at one end. Amphiphilicity can be engineered to allow for self-assembly. • Nanomicelles – very small self-assembled structure (<200 nm) capable of being used in drug delivery
Dendron • Dendron – portion of a dendrimer (lots of branching) dendron dendrimer
“Coil” Synthesis PLA-OH
Amphiphilic Dendron Coil dendron hydrophilic polyethylene glycol lipophilic polylactide coil
Self Assembly to form Nanomicelle Nanomicelle: Lipophilic Core, Hydrophilic Periphery