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Metrics, Milestones, and Timelines PSI Target Selection Meeting Stephen K. Burley November 14 th 2003

Metrics, Milestones, and Timelines PSI Target Selection Meeting Stephen K. Burley November 14 th 2003. Agenda. Status quo Examples taken from PSI-funded center websites Rationale for adopting a common system for presenting Metrics

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Metrics, Milestones, and Timelines PSI Target Selection Meeting Stephen K. Burley November 14 th 2003

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  1. Metrics, Milestones, and Timelines PSI Target Selection Meeting Stephen K. Burley November 14th 2003

  2. Agenda • Status quo • Examples taken from PSI-funded center websites • Rationale for adopting a common system for presenting Metrics • Proposed common system for presenting Metrics (i.e., PX and NMR straw men) • Center responses to the straw men • Rationale for making clear declarations of both Milestones and Timelines

  3. Status Quo • Metrics • NIGMS-mandated declaration of aggregate numbers by each PSI-funded center, but there is considerable variation in what is presented and how it is presented. • Milestones • Essentially no information. • Timelines • Essentially no information.

  4. MCSG

  5. MCSG (cont.)

  6. JCSG

  7. NYSGXRC

  8. NESGC

  9. BSGC

  10. CESG

  11. SECSG

  12. SGPP

  13. TBSGC

  14. “Problems” with Current Presentations of Metrics • Significant differences in format make it difficult to impossible to find common statistics • Significant differences in level of detail (Predictably, the most numerically successful centers are the most communicative!) • Complete absence of quarterly productivity statistics (hurts centers that are ramping up) • Incomplete information on process stage dwell time for each target (makes internal prioritization difficult to impossible)

  15. Rationale for Common Presentation of Metrics • To provide critical cumulative information regarding progress to date in the same format on every PSI center website • To provide the same statistics for each quarter • To provide a means of measuring how long a particular target spends in a particular phase of the process • To make the lives of the PSI PIs • (and John Norvell!) easier

  16. Proposed Common Presentation of Metrics I • PX Cumulative and Quarterly (effective 9/1/03) • - # target genes cloned • - # soluble targets • - # targets purified • # targets in crystallization trials • # targets abandoned • # targets giving crystals that diffract (<3Å) • # target structures phased • # target structures refined • # target structuresPDB (identify new fold)

  17. Proposed Common Presentation of Metrics II • NMR Cumulative and Quarterly (effective 9/1/03) • - # target genes cloned • - # soluble targets • - # targets purified • # targets screened by HSQC • # targets abandoned • # targets with backbone assignments • # targets with sidechain assignments • # target structures refined • # target structuresPDB (identify new fold)

  18. Discussion • MCSG-A Joachimiak • JCSG-RC Stevens • BCSG-SH Kim • TBSGC-DC Eisenberg • SESGC-BC Wang • SGPP-WGJ Hol • CESG-JL Markley • NESGX-GT Montelione

  19. Presentation of Milestones/Timelines • To provide a means of measuring progress versus goals • To quantify bottlenecks and make rational choices regarding investments in automation, etc. • To identify languishing targets and make objective decisions about whether or not and how to continue • To make John Norvell’s life easier

  20. Multiple Organisms Ensure Soluble Protein Species Af to Tm • 40 Species • 262 Gene families • 1852 Gene sets • Soluble protein(s) for 80% of gene families Gene number Summary

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