1 / 12

Biosynthesis and catabolism of pyrimidine nucleotides.

Biosynthesis and catabolism of pyrimidine nucleotides. Nucleases ( DNA -а se і RNA - ase ) decompose nucleoproteins to oligonucletides. Phosphodiesterases decompose oligonucleotides to mononucleotides. Nucleotides structure.

maille
Download Presentation

Biosynthesis and catabolism of pyrimidine nucleotides.

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Biosynthesis and catabolism of pyrimidine nucleotides.

  2. Nucleases (DNA-аse і RNA-ase) decompose nucleoproteins to oligonucletides

  3. Phosphodiesterases decompose oligonucleotides to mononucleotides Nucleotides structure

  4. Nucleoti-dases – split off phosphoric acid with the formation of nucleosides

  5. Nucleosidases decompose nuclesides to nitrogenous base and pentose Nitrogenous bases

  6. Phosphatases Nucleosidases Adenosine mononucleotide DECOMPOSITION OF MONONUCLEOTIDE

  7. DECOMPOSITION OF NUCLEIC ACIDS IN INTESTINE AND TISSUE Nucleoproteins (nucleic acids + proteins) Pepsin, gastricsin, HCl Nucleic acids + Histones, protamines Nucleases (DNA-ases, RNA-ases) Oligonucleotides Phosphodiesterases Mononucleotides Phosphatases Nuclesides + Phosphoric acid Nucleosidases Nitrogenous bases + Pentose

  8. DESTINY OF NITROGENOUS BASES, PENTOSES AND PHOSPHORIC ACIDS IN THE ORGANISM Nitrogenous bases oxidation to the end products oxidation with energy formation; synthesis of nucleotided; synthesis of hexoses; synthesis of coenzymes Pentoses phosphorilation; ATP synthesis; synthesis of phospholipids; buffer systems; constituent of bones, cartilages Phosphoric acid

  9. cytosine thimine dehydrogenase uracile dehydrogenase dihydrothimine hydrolase hydrolase dihydrouracile N-carbomoil -alanine -alanine N-carbomoil -aminoisobutirate hydrolase -aminoisobutirate Dis-integ-ration of pyri-midine nucle-otides

  10. SYNTHESIS OF PYRIMIDINE NUCLEOTIDES

  11. OROTACIDURIA • inherited disorder of pyrimidine synthesis caused by a deficiency of the enzyme of orotate-phosphoribosyltransferase anddecarboxylase. • Symptoms: • –excess of orotic acid and its excretion with urine (1.0-1.5 g) • -mental and physical retardation • -megaloblastic anemia

  12. TREATMENT OF OROTACIDURIA • Taking of uridin during the whole life

More Related