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Arabidopsis

PR-5 Fusion Proteins Of Plants. Arabidopsis. Oryza sativa. Zea mays. PR5 kinase. PR5 inositol monophosphatase. PR5 lecithin acetyltransferase. PR5 HGTP anticodon. Vitis vinifera. PR5 cytochrome P450. PR5 ELO. Adv Bot Res (2009) 17: 439-489.

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Arabidopsis

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  1. PR-5 Fusion Proteins Of Plants Arabidopsis Oryza sativa Zea mays PR5kinase PR5inositol monophosphatase PR5 lecithin acetyltransferase PR5HGTP anticodon Vitis vinifera PR5 cytochrome P450 PR5 ELO Adv Bot Res (2009) 17: 439-489.

  2. Known Functions Of PR-5/Thaumatin Like Proteins Antifungal Beta-glucanase PR5L/TLP (PR-5/thaumatin Like) Actin binding Antifreeze Xylanase inhibitor αAI/Trypsin inhibitor Cytokinin-binding Protein-Protein or/and Carbohydrate-Protein Interactions Leading To………?

  3. F. oxysporum P. infestans C. albicans S. cerevisiae Osmotin Is An Antifungal Tobacco PR-5 Protein • Induced by pathogen attack • Antifungal in planta • Specific broad-spectrum antifungal activity

  4. S. cerevisiaeIZH2 Encodes A GPCR-Like Protein That Increases Osmotin Sensitivity Osmotin  • Apoptosis is the major mechanism of toxicity • Molecular Cell (2001) 8: 921-930.  Osmotin CW PM IZH2/PHO36 RAS2/cAMP • Plasma membrane has apoptosis signaling ‘receptor’ ┴ stress responses  ROS↑ Molecular Cell (2005) 17: 171-180. Apoptosis

  5. IZH2 Is Homologous To Mammalian Adiponectin Receptors, AdipoR1 and AdipoR2 Alignment: Untitled1 ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| 10 20 30 40 50 60 70 0000000000 ---------- --MSSHKGSV VAQGNGAPAS NREADTVELA ELGPLLEEKG KRVIANPPKA EEEQTCPVPQ 0000000001 MNEPTENRLG CSRTPEPDIR LRKGHQLDGT RRGDNDSHQG DLEPILEASV LSSHHKKSSE EHEYSDEAPQ 0000000002 ---------- ---------- ---------- ---------- -MSTLLERTK SVQELKKRAA GKTSANPAE- Consensus LE ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| 80 90 100 110 120 130 140 0000000000 EEEEEVRVLT LPLQAHHAME KMEEFVYKVW EGRWRVIPYD VLPDWLKDND YLLHGHRPPM PSFRACFKSI 0000000001 EDEG-FMGMS PLLQAHHAME KMEEFVCKVW EGRWRVIPHD VLPDWLKDND FLLHGHRPPM PSFRACFKSI 0000000002 ---------- ---------- -----VAKAK KVLRRLYSWD EIPEWQRDND FILHGYVKET SSFIETFKSL Consensus V K R D P W DND LHG SF FKS ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| 150 160 170 180 190 200 210 0000000000 FRIHTETGNI WTHLLGFVLF LFLGILTMLR PNMYFMAPLQ EKVVFGMFFL GAVLCLSFSW LFHTVYCHSE 0000000001 FRIHTETGNI WTHLLGCVFF LCLGIFYMFR PNISFVAPLQ EKVVFGLFFL GAILCLSFSW LFHTVYCHSE 0000000002 FYLHNESVNI YSHLIPALGF FTVLLLDKST IKVFATTTWL DHMVIDLFYS GAFACLILSS SFHCLKSHSL Consensus F H E NI HL F V F GA CL S FH HS ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| 220 230 240 250 260 270 280 0000000000 KVSRTFSKLD YSGIALLIMG SFVPWLYYSF YCSPQPRLIY LSIVCVLGIS AIIVAQWDRF ATPKHRQTRA 0000000001 GVSRLFSKLD YSGIALLIMG SFVPWLYYSF YCNPQPCFIY LIVICVLGIA AIIVSQWDMF ATPQYRGVRA 0000000002 RIATLGNKLD YLGICILIVT SMVSILYYGY FEKFSLFCLF ALITVSFGIA CSIVSLKDKF RKREWRPYRA Consensus KLD Y GI LI S V LYY GI IV D F R RA ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| ....|....| 290 300 310 320 330 340 350 0000000000 GVFLGLGLSG VVPTMHFTIA EGFVKATTVG QMGWFFLMAV MYITGAGLYA ARIPERFFPG KFDIWFQSHQ 0000000001 GVFLGLGLSG IIPTLHYVIS EGFLKAATIG QIGWLMLMAS LYITGAALYA ARIPERFFPG KCDIWFHSHQ 0000000002 GLFVCFGLSS IIPIFSGLYC YSFSEIWTQI QLFWVLLGGV LYIIGAVLYG MRFPEKICPG KFDIWGHSHQ Consensus G F GLS P F T Q W L YI GA LY R PE PG K DIW SHQ ....|....| ....|....| ....|....| ....|.. 360 370 380 0000000000 IFHVLVVAAA FVHFYGVSNL QEFRYGLEGG CTDDTLL 0000000001 LFHIFVVAGA FVHFHGVSNL QEFRFMIGGG CSEEDAL 0000000002 LFHFLVVIAA LCHLRGLLNS YELVHIKMEN GIVS--- Consensus FH VV A H G N E Human AdipoR1 Human AdipoR2 Yeast PHO36 Consensus Human AdipoR1 Human AdipoR2 Yeast PHO36 Consensus Human AdipoR1 Human AdipoR2 Yeast PHO36 Consensus Human AdipoR1 Human AdipoR2 Yeast PHO36 Consensus Human AdipoR1 Human AdipoR2 Yeast PHO36 Consensus Human AdipoR1 Human AdipoR2 Yeast PHO36 Consensus

  6. Adiponectin gC1q Domain (Green) And Osmotin (Purple) Structures Can Be Overlapped Adiponetin gC1q collagen Molecular Cell (2005) 17: 171-180

  7. Occurence of PR-5/Thaumatin-like Proteins Species • Sequence and structural similarity with plant PR-5 proteins • As families Adv Bot Res (2009) 17: 439-489.

  8. Occurence of C1q Proteins Species • As families Adv Bot Res (2009) 17: 439-489.

  9. Do C1q Domain Proteins and Thaumatin Domain Proteins Have Similar Functions? • Most organisms have either C1q domain proteins or thaumatin domain proteins, not both • Osmotin signals in yeast through the homolog of the receptor of a mammalian C1q domain protein called adiponectin

  10. Adiponectin Is The Ligand Of AdipoR1/R2 And It Has Beneficial Effects On Human Health collagen collagen gC1q Adiponetin PM AdipoR1/AdipoR2 gC1q AMPK-P ANTI-DiabeticANTI-Atherosclerotic ANTI-Cancer ANTI-Inflammatory Bowel Disease/Colitis

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