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The reductionistic journey of the Y-chromosome the last 300 million years

The reductionistic journey of the Y-chromosome the last 300 million years Sigbritt Werner Professor in Endocrinology Karolinska Institutet. Levels of genus (lat) and gender (eng). chromosomal sex hormonal sex anatomical sex phenotypical sex sexual orientation sexual identity sexual role

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The reductionistic journey of the Y-chromosome the last 300 million years

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  1. The reductionistic journey of the Y-chromosome the last 300 million years Sigbritt WernerProfessor in EndocrinologyKarolinska Institutet

  2. Levels of genus (lat) and gender (eng) • chromosomal sex • hormonal sex • anatomical sex • phenotypical sex • sexual orientation • sexual identity • sexual role • social sex

  3. Hormonesstimulators Signal substancesinhibitors peptides steroids ions gases acids bases temperature viscositynutritional status

  4. Some gender differences in disease incidence female dominance Lupoid hepatitis type 1P Biliary CirrhosisSclerodermaSjögren’s syndromeSystemic Lupus Erythematosus hypothyroidism hyperthyroidism migrainesubarachnoid hâmorrhage multiple sclerosis ACTH prod pituitary tumours Rheumathoid ArthritisAutoimmune diseases growth hormone prod pituitary tumours 0 schizophrenia epilepsy melanoma thyroid cancer Mb Reiter Mb BechterewPelvospondylitis otherskincancers pyloric stenosisadrenal aplasia stroke X-transduced recessive diseasesHaemophiliaFabry’s syndromeAdrenoleukodystrophia male dominance

  5. Applying the sex ratio coefficient (i.e., -11.2422)from Table 1 to these values suggests that the males in Sweden's"least culled" birth cohort (i.e., 1910) lived, on average, 3 (i.e., 11.2422 x 12 x 0.0215 = 2.9) fewer months than expectedfrom the lifespan of females in that cohort as well from historictrends unique to male cohort lifespan. Those in the most "mostculled" cohort (i.e., 1784), on the other hand, lived 3.7 moremonths than was expected from history and from the lifespanof females in that cohort.

  6. This improves the mother’s chance of grandchildren since weak sons produce fewer offsprings than weak daughters

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