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The Y Chromosome

The Y Chromosome. *PAR - Pseudoautosomal region *MSY – Male-specific region of Y. *SRY – Sex determining region *TDF - Testis Determining Factor. Is the Y chromosome a “genetic wasteland”?. The Y Chromosome.

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The Y Chromosome

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  1. The Y Chromosome *PAR - Pseudoautosomal region *MSY – Male-specific region of Y *SRY – Sex determining region *TDF -Testis Determining Factor Is the Y chromosome a “genetic wasteland”?

  2. The Y Chromosome SKALETSKY, et al. (2003) The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423, 825 - 837

  3. The X Chromosome and Dosage Compensation *Do females produce twice as much of each gene product for X-linked genes? Dosage compensation *In mammals – X inactivation *Barr and Bertram *Susumo Ohno

  4. The X Chromosome and Dosage Compensation *If you can make one copy of X (in females) inactive, you can compensate for dosage Indirect evidence:

  5. X Inactivation *Lyon hypothesis Example: Coat color in cats; G6PD in human fibroblasts

  6. Review: X inactivation Mechanism of inactivation: XIC or X-inactivation center Avner, P. and Heard, E. (2001); X-CHROMOSOME INACTIVATION: COUNTING, CHOICE AND INITIATION, Nature Reviews Genetics 2; 59-67

  7. Sex determination in Drosophila:

  8. Sex determination in Drosophila:

  9. Temperature and sex determination:

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