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Amino Acids and Proteins

Amino Acids and Proteins. Amino Acids. L-isoleucine. zwitterion. Synthesis of Amino Acids. Strecker Synthesis. Gabriel Synthesis. Biosynthesis. Transamination. Polypeptides and Proteins. Carboxypeptidase. Trypsin, chymotrypsin. BrCN.

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Amino Acids and Proteins

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  1. Amino Acids and Proteins • Amino Acids

  2. L-isoleucine

  3. zwitterion

  4. Synthesis of Amino Acids • Strecker Synthesis

  5. Gabriel Synthesis

  6. Biosynthesis

  7. Transamination

  8. Polypeptides and Proteins

  9. Carboxypeptidase

  10. Trypsin, chymotrypsin

  11. BrCN

  12. Complete hydrolysis of a polypeptide gives: Gly, 3 Leu, 2 Tyr, 2 Phe, 2 Lys, Ser, 2 Met, Ala, Val, Ile, Arg, Pro • Cyanogen bromide generates a tripeptide, a heptapeptide, and an octapeptide; each is sequenced: • Leu-Pro-Phe • Gly-Leu-Trr-Phe-Lys-Ser-Met • Ala-Leu-Tyr-Lys-Val-Ile-Arg-Met

  13. Partial hydrolysis with trypsin gives a tripeptide, a tetrapeptide, a pentapeptide, and a hexapeptide; each is sequenced: • Val-Ile-Arg • Met-Leu-Pro-Phe • Gly-Leu-Tyr-Phe-Lys • Ser-Met-Ala-Leu-Tyr-Lys • What is the sequence for the original polypeptide?

  14. Polypeptide and Protein Synthesis

  15. Protecting Groups

  16. Activating Groups

  17. Automated Synthesis

  18. Secondary Structures of Polypeptides and Proteins

  19. Pleated Sheet

  20. -Helix

  21. Tertiary Structures of Polypeptides and Proteins

  22. Enzymes • Carboxypeptidase A

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