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Reporter Gene Imaging

Reporter Gene Imaging. Using antibody fragments as artificial “receptors”. Hapten 1 -X*. Hapten 2 -Y*. Ligands. Hapten-X*. Antibody fragments. B. A. Membrane anchoring domains. mRNA. mRNA. mRNA. Constitutive promoter. tissue specific promoter. DNA. Vector.

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Reporter Gene Imaging

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  1. Reporter Gene Imaging

  2. Using antibody fragments as artificial “receptors” Hapten1-X* Hapten2-Y* Ligands Hapten-X* Antibody fragments B A Membrane anchoring domains mRNA mRNA mRNA Constitutive promoter tissue specificpromoter DNA Vector

  3. Antibody reporter DAbR1 U87-DAbR1 60 tumor+ tumor- 50 blood 40 %ID/g Liver 30 20 10 0 DAbR1/ HSVtk/FHBG AABD PET/CT with Y86-DOTA Reporter Gene / Reporter Probe Comparison with HSVtk reporter

  4. Translational Molecular Imaging Hohe Sensitifität (pmol/l) Nachweis von Rezeptoren Möglich Minimalste Stoffmengen! Keine pharmakologischenEffekte

  5. Untersuchung der myokardialen Perfusion und des Sauerstoffverbrauchs mit 11C-1-acetate Ng et al. Am J Physiol 1994

  6. Untersuchung der myokardialen Perfusion und des Sauerstoffverbrauchs mit 11C-1-acetate Sun et al. J Nucl Med 1998

  7. Untersuchung der myokardialen Effizienz mit 11C-1-acetate Bengel et al. EJNM 2000

  8. Multimodale PET/CT Bildgebung LAD Stenose ohne Ischämie

  9. Multimodale PET/CT Bildgebung LCX Stenose mit ausgeprägter Ischämie

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