Site Management Organization (SMO)

1. Making Clinical Trials More Efficient Site Management Organization (SMO)

2. Core Strategic Offerings med fusionprovides successful recruiting strategies by • Increasing research and operational efficiencies • Committing to communication and coordination We make clinical trials more efficient by • Evaluating patients for rapid study startup and gathering data • Maintaining a dedicated network of healthcare providers As a result, we enhance the health, quality of life, and clinical value of patient care while increasing turn-around times and revenues.

3. med fusion Provides Solutions We promote timely and accurate payment by delivering • Fully integrated Clinical Trial Management Systems (CTMS) • Efficient accounts payable/receivable support We find appropriate studies by using • Extensive portfolios of active clinical trials • Strong relationships with sponsors We reduce costs by utilizing • Professional budget analysts to identify hidden costs in clinical trials • Field service specialists to identify and resolve front end issues • Patient Service Center (PSC) networks to optimize operations

4. med fusion Provides Solutions We make recruiting patients easy with our • Ability to evaluate patient populations for rapid study start-up • Dedicated full-time call center We streamline the negotiation of contracts with • Centralized contract review and negotiation for rapid turn-around • Established Master Service Agreements with study sponsors We ensure you stay ahead of the competition by providing • Ease of Use Model provides a platform to accelerate and drive execution at study site level • Rewarding and dynamic work environments associated with research

5. Clinical Trials with SMO Support Industry Sponsors Requests Results • med fusion • Rapid study startup • Contract and budget negotiation • Patient service centers • Site management personnel • Field service specialists • Study kit inventory and distribution • Affiliations with central IRBs Subcontracts and payments Clinical trials and patient data Sites • Oncology • CNS • CV • GI/GU • Immunology • ID

6. Connecting Sponsors and Physicians Clinical Trials Site Management and Recruitment Data Industry Sponsors Field service support Manages trials and testing Clinical Trial Site Management Support Test results Physician Offices

7. Connecting Sponsors and Physicians Clinical Trials Site Management and Recruitment Data Industry Sponsors Field service support Manages trials and testing Clinical Trial Site Management Support Reference testing Testing Physician Office Labs and Patient Service Centers Test results Health System Laboratories Community Pathology Consultations Test results Populates database Electronic Medical Records Physician Offices

8. North Texas Market med fusion provides professional, high-quality clinical research through a dedicated network of geographically distinct clinical investigative sites with large, readily available patient populations. We deliver the following resources through our unique partnerships with Baylor Healthcare System (BHCS), U.S. Oncology, and Texas Oncology. Medical resources • 624,514 outpatient registrations • 388,951 ER visits • 127,415 admissions • 6,300 medical staff members • 3,532 licensed beds Patient resources • 235 patient access points • 41 satellite outpatient clinics • 26 hospitals • 21 ambulatory surgery centers • 7 short-stay surgical hospitals

9. The med fusion Advantage To deliver effective clinical trial programs, med fusion will • Implement ongoing site relationship training • Reduce patient drop-out rates • Increase patient enrollment rates • Enable the expansion of projects to a large pool of potential patients • Build robust databases for future research and outcomes projects

10. The med fusion Advantage To deliver effective clinical trial programs, med fusion will • Increase physician participation in clinical trials • Provide an extensive IT system to access clinical trial information • Integrate systems and services to eliminate clinical trial delay • Support and enhance central and local IRB interactions • Distribute study kits on an as-needed basis through advanced logistics courier, tracking, and monitoring systems

11. Field and Patient Service Centers med fusion provides a fully integrated network of field and patient service centers that • Lower operation costs • Consolidate the processing of accounts payable/receivable • Integrate information about clinical trial availability into test results • Optimize supply storage, management, and delivery • Reduce patient attrition through dedicated field service support

12. Field and Patient Service Centers med fusionservice centers ease the burden of clinical trials via • Skilled phlebotomists who are patient friendly and service oriented • Advanced scheduling of appointments and appointment reminders • Study kit distribution on an as-needed basis

13. Enhancing Patient-Site Relationships The patient-site relationship is key to retention. med fusionbuilds and maintains strong relationships by • Identifying key factors that draw patients to clinical trials • Integrating field service specialists with sites • Ensuring adequate resources for patient recruitment • Developing patient recruitment and referral centers • Automating systems to vastly increase efficiency • Minimizing interference with other physician activities

14. The Bottom Line • Assumptions • 300 bed hospital service area (180 MDs to support) • 22 patients per study • 20 visits per patient per study per year • Average reimbursement per patient is $5,000 • Average of 3 MDs per site • Average of 18 months per clinical trial

15. Making Clinical Trials More Efficient When you rely on med fusion for Site Management Organization, we will Provide you with successful recruiting strategies. Connect you with physicians to successfully initiate and operate patient studies. Deliverprofessional, high-quality clinical research through a dedicated network of geographically distinct clinical investigative sites with large, readily available patient populations. Implementa fully integrated network of field and patient service centers that benefit your organization.

16. References Acurian Whitepaper Series: Scott H. Connor, VP Marketing,An Integrated Approach for Clinical Trial Patient Retention. Elvidge S. Importance of Patient-Retention Strategies. Life Science Leader. April 2010. Kaitin KI. Growing Protocol Design Complexity Stresses Investigators, Volunteers. Impact Report. Tufts Center for the Study of Drug Development. 2008. Wipke-Tevis, D. Impact of the Health Insurance Portability and Accountability Act of participant recruiting and retention. Western Journal of Nursing. 2008;30:399-53. 5th Annual Patient Recruitment & Retention Conference; September 24-25, 2007; Washington, DC; data presented by John Benbrook and Malcolm Bohm of MMG & Trialytics, Inc. Volunteer Demographics Center for Information & Study on Clinical Research, Clinical Trial Facts and Figures, 2006.