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Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct

Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct Catenin Subfamilies Promote Wnt Signals. Park et al . Dev Cell . (2006). Linear structural representation of catenin family proteins. McCrea et al. Biochim Biophys Acta. (2006).

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Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct

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  1. Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct Catenin Subfamilies Promote Wnt Signals Park et al. Dev Cell. (2006)

  2. Linear structural representation of catenin family proteins McCrea et al. Biochim Biophys Acta. (2006)

  3. Signaling pathways and interactions involving p120-catenin • Cadherin stability • Phosphorylation • Transcription • Small G protein • Inflammation / proliferation McCrea et al. Biochim Biophys Acta. (2006)

  4. Molecular complexes of Kaiso and LEF/TCF with armadillo proteins in thenucleus BTB/POZ-ZF : Broad complex, Tramtrack, Bric a brac(BTB) or poxvirus and zinc finger (POZ)-ZF. Implicated in tumorigenesis. Kaiso : Transcriptional repressor and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA. van Roy et al. Nat Rev Cancer. (2005)

  5. Model depicting the E-cadherin–catenin cell adhesion complex and signaling pathways Daniel et al. Biochim Biophys Acta. (2006)

  6. Schematic representation of p120ctn and its nuclear binding partner Kaiso Daniel et al. Biochim Biophys Acta. (2006)

  7. Frodo comes into Wnt signaling Frodo interacts with Dishevelled to transduce Wnt signals Nat Cell Biol. (2002) Two Frodo/Dapper Homologs Are Expressed in the Developing Brain and Mesoderm of Zebrafish Dev Dyn. (2004) The involvement of Frodo in TCF-dependent signaling and neural tissue development Development. (2004) A Vertebrate Homolog of the Cell Cycle Regulator Dbf4 Is an Inhibitor of Wnt Signaling Required for Heart Development Dev Cell. (2005) Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements Dev Dyn. (2006)

  8. A role for Frd1, a Dsh-associated protein, in Wnt signaling Brott BK and Sokol SY. Differentiation. (2005)

  9. Interaction between p120-Catenin and Frodo

  10. Frodo Regulation of the xKaiso Target Gene, xWnt-11 Wnt11 KCS : Kaiso consensus site CTGCNA

  11. Inhibition of Kaiso:DNA Association by Frodo Figure S1.

  12. : blastopore Frodo Partially Rescues Kaiso-Induced Gastrulation Failures PCP Frodo Dsh-∆DEP p120 Kaiso Wnt11 Kaiso

  13. Frodo Depletion Destabilizes p120ctn while Frodo Overexpression Stabilizes p120ctn

  14. Dsh Regulates p120-Catenin Protein Stability

  15. Wnt-Ligand Induced Signaling Inhibits Kaiso:Promoter Association Figure S3.

  16. Dsh Regulates p120-Catenin Protein Stability

  17. Model of the Frodo/p120-Catenin/Kaiso Signaling Module in Relation to Wnt Ligand Activation of Frizzled/LRP Coreceptor

  18. ? Frodo Frodo Inhibits Rho A Activity Figure S4.

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